Fig. 1

Interaction graph of the core model. LPS (L) in the intestinal lumen environment enters the epithelial cell through leaky barrier, butyrate (B) via transporter channel. Butyrate enhances barrier function of epithelial cells and blocks LPS to enter. Transport of lumen butyrate into the cell is blocked by cytokines (T). L, T, NF- κB (N) and repressors (R) are representing the inflammatory model variables in the model by [57] which interact with butyrate (B), as described above and by B blocking NF- κB’s transport into the nucleus (modelled as blocking NF- κB). Black arrows represent transport, green arrows activation, red arrows inhibition