Fig. 3
From: Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors
Model comparison to validation data. a The differences in pERK induced by stimulation of FGF with and without 500 μg/ml heparin at four time points are predicted. Each dot represents one fit. The dots are spread horizontally to avoid overlap of similar responses from different fits. b Normalized pERK by the stimulation of 10 ng/ml FGF. Circles are BAEC experimental data. c Normalized VEGFR2 phosphorylation time course upon stimulation with 80 ng/ml VEGF. Circles are HUVEC experimental data. Curves are the mean values of the 16 best fits from the model training. Shaded regions show standard deviation of the fits