Fig. 7
From: Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors
Effect of varying VEGFR2 trafficking parameters on pERK response. a Maximum pERK, b T1, and (c) T2. The panels show the effect of 0.5 nM FGF (Yellow) or 0.5 nM VEGF (Blue) predicted using the fitted parameter values (“fitted” x-axis label). We ran the model with 0.5 nM VEGF when all of the VEGFR2 trafficking parameters are decreased (“all” x-axis label) to be the same as the FGFR trafficking rates shown in Additional file 1: Figure S5. Finally, we decreased each VEGFR2 trafficking parameter individually to be the same as the corresponding FGFR trafficking rate shown in Additional file 1: Figure S5. We omitted some points for T1 and T2 when the pERK does not reach the maximum value in two hours. Each dot represents one fit. Bars are median ± 95% confidence interval