Fig. 5

Role of OGT in Cancer Progression: Parameter Estimation, qualitative model generation and discovery of important properties(A-C). In (a) Heatmap of four sets of logical parameters is shown. These parameters are computed from CTL observations used in [48] by using our Parallel Implementation. The parameter sets are numbered from M1 to M4. b The stategraph is generated from parameter set M4 used in [48].The stategraph comprises of 512 nodes and 2304 edges. The order of states in stategraph is (NFkB,P21,FoXM1,PI3K,P53,MDM2,OGT,OGA,Cmyc). (c) The trajectories in the qualitative model show different possibilities reaching to the deadlock state (1,0,1,1,1,1,1,0,1) with high oncogenic expression levels along with elevated OGT levels or homeostasis/cycle comprising of four states