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Fig. 6 | BMC Systems Biology

Fig. 6

From: Parameter estimation of qualitative biological regulatory networks on high performance computing hardware

Fig. 6

a Parameter estimation after therapeutic intervention. b Trajectory showing recovery from high oncogenic levels to normal homeostasis. We eliminate of CTL observation (OGT=1,OGA=0) → EF(AG(OGT=1,OGA=0,PI3K=1,FoXM1=1,P21=0,CMyc=1)) that encodes the occurrence of the deadlock state with high oncogenic expression levels. The parameter computation results show 28 different sets of logical parameters. These models do not have the deadlock state (1,0,1,1,1,1,1,0,1) reported in [48]. The parameter estimation was performed using our parallel implementation. The parameters are numbered from M1 to M2 and rendered as a heatmap. Each column represents a unique set of parameters. The expression of parameters is represented with green rectangles whereas the down-regulated values are shown as orange rectangles. The result shows that in order to avoid the deadlock state, the parameters of OGT must be at low expression. b The trajectory in the qualitative model obtained from one of the 28 parameter sets show that from state (1,0,1,1,1,1,1,0,1), the system is able to reach to normal homeostasis (cycle). The order of states is (NFkB,P21,FoXM1,PI3K,P53,MDM2,OGT,OGA,Cmyc)

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