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Fig. 2 | BMC Systems Biology

Fig. 2

From: Multi-omics integration reveals molecular networks and regulators of psoriasis

Fig. 2

Comparison of significant pathways between GWAS and EWAS. Panels A-D represent significant canonical pathways/coexpression modules from Biocarta (a), Reactome (b), KEGG (c), and coexpression networks (d), respectively, that are associated with in psoriasis in GWAS and EWAS. The detailed MSEA results in GWAS and EWAS can be found in Additional file 1: Tables S5 and S6. The pathways are derived from various databases including Biocarta, Reactome, and KEGG, and were intersected with GWAS or EWAS using our MSEA procedure to identify pathways whose genes contain genetic or epigenetic variants showing coordinated association with psoriasis in GWAS or EWAS. “BCAA biosynthesis” stands for branched chain amino acids biosynthesis. In Additional file 1: Table S5, the corresponding full pathway name is “valine, leucine, and isoleucine biosynthesis”, where valine, leucine, and isoleucine are BCAAs

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