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Fig. 5 | BMC Systems Biology

Fig. 5

From: Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone

Fig. 5

Pathway rewiring associated to different biological transitions. Each panel shows a network of communities identified in each transition: health to disease in panel a, disease to treatment in panel b, and treatment to health in panel c. In panel a, the “GPCR signaling community” is connected to the “ECM organization community” but not to the “neuronal system community.” In panel b, only four communities—“ECM organization community,” “GPCR signaling community,” “SLC-mediated transport community,” and “neuronal system community”—survived with no connections between communities. In panel c, the “GPCR signaling community” exhibits a rewiring, with a new connection (shown with a thicker line in the image) to the “neuronal system community.” A gray outline indicates the community that contains the “hemostasis” pathway, which changes in each transition as a consequence of pathway rewiring: it initially belongs to the “GPCR signaling community,” it is not found in any community in panel b (as it is not perturbed in this transition), and finally, it belongs to the “ECM organization community”

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