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Fig. 2 | BMC Systems Biology

Fig. 2

From: DynamicME: dynamic simulation and refinement of integrated models of metabolism and protein expression

Fig. 2

Schematic of the DynamicME procedure. The culture is divided into smaller time steps and extracellular concentrations and biomass are updated at each timepoint. Metabolite exchange fluxes are computed whenever substrate availability changes due to metabolite depletion, feed, or secretion. With each ME simulation, the metabolic flux distribution and proteome composition are also updated

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