Fig. 1
a Network scheme of the liver regeneration model. b Comparison of approaches for translating the model across species. Regeneration profile corresponding to patient ID71 [18] obtained via the three approaches: empirically scaling only the metabolic load based on species body mass [21], scaling metabolic load based on body mass along with modifying the relative cell mass growth constant (kG) to 6.5675e-4 for human case [8], and present multivariate optimization approach where all the model parameters were allowed to be tuned. c Relative variation of all the 33 parameters of the model scaled by Cook et al. [8] parameters for rat