Fig. 6From: Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resectionPhase portrait for quiescent (Q) and replicating (R) cell fractions with varying levels of metabolic load parameter M. All other parameters were set to the optimal levels given in Table 1 The filled circle markers in a-c represent different levels of resection. The red dashed curves represent trajectories for the critical level of resection at and above which failure occurs. a M = 4, yields a threshold of liver failure at 87% resection. b M = 12, yields a threshold of liver failure at 56% resection. c M = 22, for which there is no safe level of resection. d Influence of metabolic load on the threshold of liver failure. Red cross markers in panel d represent the threshold of failure for the corresponding phase planes a-cBack to article page