Table 2 Model parameters categorized according to the effect on liver response profile, leading to recovery alone, or causing either recovery or failure depending on the parameter value
Only recovery | Both recovery and failure | |||
|---|---|---|---|---|
Sensitive | Insensitive | Sensitive | Insensitive | |
Improves recovery | Decelerate recovery | |||
\( {\displaystyle \begin{array}{l}{k}_{IL6},\left[ prosSTAT3\right],\\ {}{\kappa}_{SOCS3},{K}_I^{SOCS3},{V}_{IE},\\ {}{k}_{\mathrm{deg}},{k}_{GF},{k}_{QP},{k}_{PR},\\ {}{k}_{prol},{\beta}_{req},{k}_G\end{array}} \) | \( {\displaystyle \begin{array}{l}{\kappa}_{IL6},{K}_M^{JAK},{\kappa}_{JAK},\\ {}{K}_M^{ST3},{V}_{SOCS3},\\ {}{K}_M^{SOCS3},{K}_M^{IE},{\kappa}_{IE},\\ {}{\kappa}_{ECM},{\kappa}_{GF},{k}_{up},\\ {}{k}_{RQ},{k}_{req}\end{array}} \) | \( {\displaystyle \begin{array}{l}{V}_{JAK},{V}_{ST3},{\kappa}_{ST3},\\ {}\;{\theta}_{req},{k}_{ap}\end{array}} \) | M, βap | θ ap |