Skip to main content

Advertisement

Table 2 Model parameters categorized according to the effect on liver response profile, leading to recovery alone, or causing either recovery or failure depending on the parameter value

From: Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resection

Only recovery Both recovery and failure
Sensitive Insensitive Sensitive Insensitive
Improves recovery Decelerate recovery
\( {\displaystyle \begin{array}{l}{k}_{IL6},\left[ prosSTAT3\right],\\ {}{\kappa}_{SOCS3},{K}_I^{SOCS3},{V}_{IE},\\ {}{k}_{\mathrm{deg}},{k}_{GF},{k}_{QP},{k}_{PR},\\ {}{k}_{prol},{\beta}_{req},{k}_G\end{array}} \) \( {\displaystyle \begin{array}{l}{\kappa}_{IL6},{K}_M^{JAK},{\kappa}_{JAK},\\ {}{K}_M^{ST3},{V}_{SOCS3},\\ {}{K}_M^{SOCS3},{K}_M^{IE},{\kappa}_{IE},\\ {}{\kappa}_{ECM},{\kappa}_{GF},{k}_{up},\\ {}{k}_{RQ},{k}_{req}\end{array}} \) \( {\displaystyle \begin{array}{l}{V}_{JAK},{V}_{ST3},{\kappa}_{ST3},\\ {}\;{\theta}_{req},{k}_{ap}\end{array}} \) M, βap θ ap