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Table 1 Effects of conditional (RU486-induced) upd1 gene overexpression in intestinal cells (TIGS-2), fat body cells (Switch1.32) and nervous system cells (ELAV-GS) on the lifespan of imago Drosophila melanogaster

From: Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster

Genotype Variant Sex M dM Cox-Mantel test 90% d90% Wang–Allison test MRDT dMRDT α R0 n
UAS-upd/TIGS-2 -RU486 37    44    5.5   0.12519 0.00094 345
UAS-upd/TIGS-2 +RU486 17 −54.1 p < 0.001 26 −40.9 p < 0.001 5.5 −0.3 0.12555 0.00934 454
UAS-upd/TIGS-2 -RU486 37    47    5.6   0.12277 0.00087 423
UAS-upd/TIGS-2 +RU486 30 −18.9 p < 0.001 38 −19.1 p < 0.001 4.9 −12.4 0.14013 0.0015 470
UAS-upd/Switch1.32 -RU486 62    67    6.3   0.10991 0.00013 283
UAS-upd/Switch1.32 +RU486 61 −1.6 p > 0.05 72 7.5 p < 0.0001 7.3 16.4 0.09445 0.00023 312
UAS-upd/Switch1.32 -RU486 59    68    5.6   0.12379 0.00007 283
UAS-upd/Switch1.32 +RU486 57 −3.4 p > 0.05 68 0.0 p > 0.05 6.5 15.9 0.10679 0.00019 336
UAS-upd/ELAV-GS -RU486 43.5    61    8.9   0.07795 0.0016 449
UAS-upd/ELAV-GS +RU486 57 31.0 p < 0.001 64 4.9 p > 0.05 6.0 −32.1 0.11475 0.00016 417
UAS-upd/ELAV-GS -RU486 52    60    6.5   0.10705 0.00033 448
UAS-upd/ELAV-GS +RU486 52 0.0 p > 0.05 61 1.7 p > 0.05 6.4 −0.7 0.10776 0.00031 462
  1. RU486 – control, without mifepristone; +RU486 – overexpression, with mifepristone; ♂ – males; ♀ – females; М – (days); 90% – age of 90% mortality (days); MRDT – mortality rate doubling time (days); α and R0 – Gompertz equation parameters; n – sample size. dМ, d90%, dMRDT – the differences in median lifespan, age of 90% mortality and MRDT estimated between -RU486 and + RU486 variants (%)