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Table 1 Effects of conditional (RU486-induced) upd1 gene overexpression in intestinal cells (TIGS-2), fat body cells (Switch1.32) and nervous system cells (ELAV-GS) on the lifespan of imago Drosophila melanogaster

From: Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster

Genotype

Variant

Sex

M

dM

Cox-Mantel test

90%

d90%

Wang–Allison test

MRDT

dMRDT

α

R0

n

UAS-upd/TIGS-2

-RU486

37

  

44

  

5.5

 

0.12519

0.00094

345

UAS-upd/TIGS-2

+RU486

17

−54.1

p < 0.001

26

−40.9

p < 0.001

5.5

−0.3

0.12555

0.00934

454

UAS-upd/TIGS-2

-RU486

37

  

47

  

5.6

 

0.12277

0.00087

423

UAS-upd/TIGS-2

+RU486

30

−18.9

p < 0.001

38

−19.1

p < 0.001

4.9

−12.4

0.14013

0.0015

470

UAS-upd/Switch1.32

-RU486

62

  

67

  

6.3

 

0.10991

0.00013

283

UAS-upd/Switch1.32

+RU486

61

−1.6

p > 0.05

72

7.5

p < 0.0001

7.3

16.4

0.09445

0.00023

312

UAS-upd/Switch1.32

-RU486

59

  

68

  

5.6

 

0.12379

0.00007

283

UAS-upd/Switch1.32

+RU486

57

−3.4

p > 0.05

68

0.0

p > 0.05

6.5

15.9

0.10679

0.00019

336

UAS-upd/ELAV-GS

-RU486

43.5

  

61

  

8.9

 

0.07795

0.0016

449

UAS-upd/ELAV-GS

+RU486

57

31.0

p < 0.001

64

4.9

p > 0.05

6.0

−32.1

0.11475

0.00016

417

UAS-upd/ELAV-GS

-RU486

52

  

60

  

6.5

 

0.10705

0.00033

448

UAS-upd/ELAV-GS

+RU486

52

0.0

p > 0.05

61

1.7

p > 0.05

6.4

−0.7

0.10776

0.00031

462

  1. RU486 – control, without mifepristone; +RU486 – overexpression, with mifepristone; ♂ – males; ♀ – females; М – (days); 90% – age of 90% mortality (days); MRDT – mortality rate doubling time (days); α and R0 – Gompertz equation parameters; n – sample size. dМ, d90%, dMRDT – the differences in median lifespan, age of 90% mortality and MRDT estimated between -RU486 and + RU486 variants (%)