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Table 2 Example of drug-protein interaction signature: association between adverse drug reaction (ADR) (R01631 Graft-versus-host disease) and protein domain (PF14446 Prokaryotic RING finger family 1)

From: Network-based characterization of drug-protein interaction signatures with a space-efficient approach

Extracted ADR R01631 Graft-versus-host disease
Extracted domain PF14446 Prokaryotic RING finger family 1
Drugs sharing the extracted ADR D00322 Fluconazole (antifungal)
  D00333 Ganciclovir (antiviral)
  D00399 Valproic acid (anticonvulsant)
  D00407 Methylprednisolone (glucocorticoid)
  D06272 Sorafenib tosilate (anticancer, antineoplastic)
  D06413 Nilotinib hydrochloride (antineoplastic)
  D08062 Idarubicin (antineoplastic, antibiotic)
  D08066 Imatinib (antineoplastic)
  D08524 Sorafenib (antineoplastic, anticancer)
  D08556 Tacrolimus (immunosuppressant)
Proteins sharing extracted domain hsa:5587,hsa:23683,hsa:25865 protein kinase D
  hsa:51317 PHD finger protein 21A
  hsa:5580 protein kinase C
  hsa:64283 Rho guanine nucleotide exchange factor
  hsa:673 B-Raf proto-oncogene protein kinase
  hsa:80829 ZFP91 zinc finger protein
  1. Further details are given in Fig. 5