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Table 2 Example of drug-protein interaction signature: association between adverse drug reaction (ADR) (R01631 Graft-versus-host disease) and protein domain (PF14446 Prokaryotic RING finger family 1)

From: Network-based characterization of drug-protein interaction signatures with a space-efficient approach

Extracted ADR

R01631 Graft-versus-host disease

Extracted domain

PF14446 Prokaryotic RING finger family 1

Drugs sharing the extracted ADR

D00322 Fluconazole (antifungal)

 

D00333 Ganciclovir (antiviral)

 

D00399 Valproic acid (anticonvulsant)

 

D00407 Methylprednisolone (glucocorticoid)

 

D06272 Sorafenib tosilate (anticancer, antineoplastic)

 

D06413 Nilotinib hydrochloride (antineoplastic)

 

D08062 Idarubicin (antineoplastic, antibiotic)

 

D08066 Imatinib (antineoplastic)

 

D08524 Sorafenib (antineoplastic, anticancer)

 

D08556 Tacrolimus (immunosuppressant)

Proteins sharing extracted domain

hsa:5587,hsa:23683,hsa:25865 protein kinase D

 

hsa:51317 PHD finger protein 21A

 

hsa:5580 protein kinase C

 

hsa:64283 Rho guanine nucleotide exchange factor

 

hsa:673 B-Raf proto-oncogene protein kinase

 

hsa:80829 ZFP91 zinc finger protein

  1. Further details are given in Fig. 5