Skip to main content

Advertisement

Table 2 Boolean functions for the Boolean model

From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

Node Boolean function Node Boolean function
ER ER OS OS
FasL FasL TNF α TNF α or NFKB
IL-6 IL-6 or NFKB   
GRP78 ATF6 or XBP1 or ATF4 and (not ER) ATF6 GRP78
PERK GRP78 and (not DNAJC3) IRE1 BAX or BAK or GRP78
EIF2S1 GADD34 and (not PERK) DNAJC3 ATF6 or XBP1
ATF4 EIF2S1 CHOP ATF6 or ATF4
XBP1 IRE1 GADD34 CHOP
TNFR1 TNF α TNFR2 TNF α
TRAF2 IRE1 or TNFR2 or TRADD ASK1 OS or TRAF2 or DAXX
JNK OS or ASK1 or GADD45 p38 OS or ASK1
BCL2 (not JNK) and (not CHOP) and (not P53) and (not BAD) BID CASP8 and (not BCL2)
BAX JNK or P53 and (not BCL2) BAK BAX and (not BCL2)
DIABLO BAX or BAK or BID HtrA2 BAX or BAK or BID
FasR FasL TRADD TNFR1
DAXX FasR RIPK1 FasR or TRADD
RAIDD RIPK1 FADD FasR or TRADD
CASP8 RAIDD or FADD or CASP3 or CASP6 CASP9 RAIDD or CASP8 or CASP3 or APAF1 or CASP12 and (not XIAP) and (not AKT)
CASP3 CASP9 or CASP8 and (not XIAP) CASP7 CASP9 or CASP8 or CASP3 or CASP6 and (not XIAP)
CASP6 CASP7 or CASP3   
XIAP (not DIABLO) and (not HtrA2) (not CASP3) CytochromeC BAX or BAK or BID
APAF1 CytochromeC or P53 Apoptosis CASP3 or CASP6 or CASP7
INS INS INSR INS
IRS INSR and (not SOCS3) and (not JNK) (not IKK β) and (not S6K) PI3K IRS or JAK
PIP3 PI3K PDK1 PIP3
AKT PDK1 or mTORC2 and (not TRB3) AS160 AKT
PKC α PDK1 GLUT4 AKT or AS160 or PKC α
GSK3 β not AKT GS not GSK3 β
FOXO1 PERK and (not AKT) and (not XBP1) PGC1 α FOXO1
PEPCK FOXO1 G6PC FOXO1
PPAR α PGC1 α TRB3 PPAR α or CHOP
TSC1/2 (not AKT) and (not IKK β) Rheb not TSC1/2
mTORC1 Rheb S6K mTORC1
mTORC2 not S6K BAD JNK and (not AKT)
JAK IL-6 and (not SOCS3) STAT3 JAK
SOCS3 STAT3 IKK β TRAF2
NF κB not IKB α IKB α not IKK β