Table 2 Boolean functions for the Boolean model
From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus
| Node | Boolean function | Node | Boolean function |
|---|---|---|---|
| ER | ER | OS | OS |
| FasL | FasL | TNF α | TNF α or NFKB |
| IL-6 | IL-6 or NFKB | ||
| GRP78 | ATF6 or XBP1 or ATF4 and (not ER) | ATF6 | GRP78 |
| PERK | GRP78 and (not DNAJC3) | IRE1 | BAX or BAK or GRP78 |
| EIF2S1 | GADD34 and (not PERK) | DNAJC3 | ATF6 or XBP1 |
| ATF4 | EIF2S1 | CHOP | ATF6 or ATF4 |
| XBP1 | IRE1 | GADD34 | CHOP |
| TNFR1 | TNF α | TNFR2 | TNF α |
| TRAF2 | IRE1 or TNFR2 or TRADD | ASK1 | OS or TRAF2 or DAXX |
| JNK | OS or ASK1 or GADD45 | p38 | OS or ASK1 |
| BCL2 | (not JNK) and (not CHOP) and (not P53) and (not BAD) | BID | CASP8 and (not BCL2) |
| BAX | JNK or P53 and (not BCL2) | BAK | BAX and (not BCL2) |
| DIABLO | BAX or BAK or BID | HtrA2 | BAX or BAK or BID |
| FasR | FasL | TRADD | TNFR1 |
| DAXX | FasR | RIPK1 | FasR or TRADD |
| RAIDD | RIPK1 | FADD | FasR or TRADD |
| CASP8 | RAIDD or FADD or CASP3 or CASP6 | CASP9 | RAIDD or CASP8 or CASP3 or APAF1 or CASP12 and (not XIAP) and (not AKT) |
| CASP3 | CASP9 or CASP8 and (not XIAP) | CASP7 | CASP9 or CASP8 or CASP3 or CASP6 and (not XIAP) |
| CASP6 | CASP7 or CASP3 | ||
| XIAP | (not DIABLO) and (not HtrA2) (not CASP3) | CytochromeC | BAX or BAK or BID |
| APAF1 | CytochromeC or P53 | Apoptosis | CASP3 or CASP6 or CASP7 |
| INS | INS | INSR | INS |
| IRS | INSR and (not SOCS3) and (not JNK) (not IKK β) and (not S6K) | PI3K | IRS or JAK |
| PIP3 | PI3K | PDK1 | PIP3 |
| AKT | PDK1 or mTORC2 and (not TRB3) | AS160 | AKT |
| PKC α | PDK1 | GLUT4 | AKT or AS160 or PKC α |
| GSK3 β | not AKT | GS | not GSK3 β |
| FOXO1 | PERK and (not AKT) and (not XBP1) | PGC1 α | FOXO1 |
| PEPCK | FOXO1 | G6PC | FOXO1 |
| PPAR α | PGC1 α | TRB3 | PPAR α or CHOP |
| TSC1/2 | (not AKT) and (not IKK β) | Rheb | not TSC1/2 |
| mTORC1 | Rheb | S6K | mTORC1 |
| mTORC2 | not S6K | BAD | JNK and (not AKT) |
| JAK | IL-6 and (not SOCS3) | STAT3 | JAK |
| SOCS3 | STAT3 | IKK β | TRAF2 |
| NF κB | not IKB α | IKB α | not IKK β |