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Table 5 Gene expressions of the significant genes in the model for input signal cases 1-5 and 7-8

From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

Node Case 1 Case 2 Case 3 Case 4 Case 5 Case 7 Case 8
  A1 A2 A1 A2 A1 A2 A1 A2 A1 A2 A1 A2 A1 A2
Apoptosis 1 1 1 1 1 1 1 1 1 1 1 1 1 1
AKT 0.50 0.50 0.49 0.49 0.49 0.49 0.49 0.49 0.50 0.49 0.49 0.50 0.50 0.49
APAF-1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
ASK1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
ATF4 1 0 1 0 1 0 1 0 1 0 1 0 1 0
ATF6 0 0 0 0 0 0 0 0 0 0 0 0 0 0
BAK 1 1 1 1 1 1 1 1 1 1 1 1 1 1
BAX 1 1 1 1 1 1 1 1 1 1 1 1 1 1
BCL2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Caspase-3 1 1 1 1 1 1 1 1 1 1 1 1 1 1
Caspase-6 1 1 1 1 1 1 1 1 1 1 1 1 1 1
Caspase-7 1 1 1 1 1 1 1 1 1 1 1 1 1 1
Caspase-8 1 1 1 1 1 1 1 1 1 1 1 1 1 1
Caspase-9 1 1 1 1 1 1 1 1 1 1 1 1 1 1
CHOP 1 0 1 0 1 0 1 0 1 0 1 0 1 0
DIABLO 1 1 1 1 1 1 1 1 1 1 1 1 1 1
EIF2S1 1 0 1 0 1 0 1 0 1 0 1 0 1 0
FADD 1 1 1 1 1 1 1 1 1 1 1 1 1 1
FASR 0 0 0 0 0 0 0 0 0 0 0 0 0 0
FOXO1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
G6PC 0 0 0 0 0 0 0 0 0 0 0 0 0 0
GADD34 1 0 1 0 1 0 1 0 1 0 1 0 1 0
GLUT4 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65
GRP78 1 1 1 1 1 1 1 1 1 1 1 1 1 1
GS 0.50 0.50 0.50 0.49 0.49 0.49 0.49 0.49 0.50 0.50 0.50 0.50 0.50 0.49
GSK3 β 0.49 0.49 0.50 0.50 0.50 0.50 0.50 0.50 0.49 0.49 0.49 0.49 0.49 0.50
HtrA2 1 1 1 1 1 1 1 1 1 1 1 1 1 1
IKB α 0 0 0 0 0 0 0 0 0 0 0 0 0 0
IKK β 1 1 1 1 1 1 1 1 1 1 1 1 1 1
INS 1 1 1 1 1 1 1 1 1 1 1 1 1 1
INSR 1 1 1 1 1 1 1 1 1 1 1 1 1 1
IRE1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
IRS 0 0 0 0 0 0 0 0 0 0 0 0 0 0
JAK 0.50 0.49 0.50 0.49 0.49 0.50 0.49 0.49 0.49 0.49 0.49 0.50 0.50 0.50
JNK 1 1 1 1 1 1 1 1 1 1 1 1 1 1
NFKB 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PEPCK 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PERK 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PI3K 0.50 0.49 0.49 0.49 0.50 0.50 0.50 0.50 0.50 0.49 0.49 0.50 0.50 0.49
RAIDD 1 1 1 1 1 1 1 1 1 1 1 1 1 1
RIPK1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
S6K 1 1 1 1 1 1 1 1 1 1 1 1 1 1
SOCS3 0.49 0.49 0.50 0.49 0.50 0.50 0.49 0.49 0.50 0.50 0.49 0.49 0.49 0.50
STAT3 0.50 0.49 0.49 0.49 0.49 0.50 0.49 0.49 0.50 0.50 0.49 0.49 0.50 0.50
TNFR1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TNFR2 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TRADD 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TRAF2 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TRB3 1 0 1 0 1 0 1 0 1 0 1 0 1 0
TSC2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
XBP1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
XIAP 0 0 0 0 0 0 0 0 0 0 0 0 0 0
mTORC1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
p38 1 1 1 1 1 1 1 1 1 1 1 1 1 1
  1. Here A1 and A2 denotes SCC1 and SCC2