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Table 6 Gene expressions of the significant genes in the model for input signal case 6. Here A1-A6 denotes SCC1-SCC6

From: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

Node Case 6
  A1 A2 A3 A4 A5 A6
Apoptosis 1 1 1 1 0 0
AKT 0.49 0.49 0.63 0.55 0.65 0.56
APAF-1 1 1 0 1 0 0
ASK1 1 1 0 0 0 0
ATF4 1 0 0 1 0 1
ATF6 0 0 0 0 0 0
BAK 1 1 0 0 0 0
BAX 1 1 0 0 0 0
BCL2 0 0 1 0 1 0
Caspase-3 1 1 1 1 0 0
Caspase-6 1 1 1 1 0 0
Caspase-7 1 1 1 1 0 0
Caspase-8 1 1 1 1 0 0
Caspase-9 1 1 1 1 0 0
CHOP 1 0 0 1 0 1
DIABLO 1 1 0 1 0 0
EIF2S1 1 0 0 1 0 1
FADD 1 1 0 0 0 0
FASR 0 0 0 0 0 0
FOXO1 0 0 0 0 0 0
G6PC 0 0 0 0 0 0
GADD34 1 0 0 1 0 1
GLUT4 0.65 0.65 0.75 0.70 0.78 0.71
GRP78 1 1 0 1 0 1
GS 0.49 0.49 0.62 0.54 0.65 0.55
GSK3 β 0.50 0.50 0.38 0.45 0.36 0.45
HtrA2 1 1 0 1 0 0
IKB α 0 0 1 1 1 1
IKK β 1 1 0 0 0 0
INS 1 1 1 1 1 1
INSR 1 1 1 1 1 1
IRE1 1 1 0 0 0 0
IRS 0 0 0.19 0.22 0.18 0.22
JAK 0.49 0.49 0.49 0.49 0.49 0.50
JNK 1 1 0 0 0 0
NFKB 1 1 0 0 0 0
PEPCK 0 0 0 0 0 0
PERK 0 0 0 0 0 0
PI3K 0.49 0.49 0.54 0.55 0.54 0.56
RAIDD 1 1 0 0 0 0
RIPK1 1 1 0 0 0 0
S6K 1 1 0.62 0.55 0.62 0.56
SOCS3 0.49 0.50 0.50 0.49 0.49 0.49
STAT3 0.49 0.49 0.49 0.49 0.49 0.50
TNFR1 1 1 0 0 0 0
TNFR2 1 1 0 0 0 0
TRADD 1 1 0 0 0 0
TRAF2 1 1 0 0 0 0
TRB3 1 0 0 1 0 1
TSC2 0 0 0.37 0.45 0.36 0.44
XBP1 1 1 0 0 0 0
XIAP 0 0 0 0 1 1
mTORC1 1 1 0.63 0.55 0.63 0.57
p38 1 1 0 0 0 0