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Fig. 2 | BMC Systems Biology

Fig. 2

From: Predicting disease-related phenotypes using an integrated phenotype similarity measurement based on HPO

Fig. 2

The workflow of DisPheno. It mainly contains four parts: a Annotating phenotype ontology information content using both gene annotation and disease annotation; b Reconstructing topological structure of phenotype term by calculating phenotype term definition similarity using TF-IDF; c Measuring phenotype semantic similarity based on HPO by integrating term definition-similarity; d Calculating phenotype term association and set similarity by measuring phenotype term associations using Point-wise Mutual Information(PMI)

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