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Table 2 The top enriched GO pathways (pathway size <100; enrichment p-value < 0.1) which also significantly correlated with treatment response (|correlation|> 0.7; correlation p-value < 0.01)

From: Anti-TNF- αtreatment-related pathways and biomarkers revealed by transcriptome analysis in Chinese psoriasis patients

GO Pathway Treatment response correlation GO-Enrichment Pvalue M_DEG
Heparan sulfate proteoglycan metabolic process 0.81 2.50E-06 EXTL3, HPSE, NDST1, SULF2
Cellular carbohydrate catabolic process 0.86 0.00135 GK5, MGAM, PYGL
Positive regulation of CD4-positive, alpha-beta T cell activation 0.90 0.00268 CD55, CD83
Hair follicle development 0.80 0.00273 HPSE, LAMA5, TGM3
Molting cycle process 0.80 0.00273 HPSE, LAMA5, TGM3
Hair cycle process 0.80 0.00273 HPSE, LAMA5, TGM3
Skin epidermis development 0.80 0.00283 HPSE, LAMA5, TGM3
Positive regulation vascular endothelial growth factor production 0.74 0.00317 HPSE, SULF2
Glucan catabolic process 0.88 0.00369 MGAM, PYGL
Cellular polysaccharide catabolic process 0.88 0.00397 MGAM, PYGL
Regulation of vascular endothelial growth factor production 0.79 0.00425 HPSE, SULF2
Polysaccharide catabolic process 0.88 0.00454 MGAM, PYGL
Vascular endothelial growth factor production 0.76 0.00485 HPSE, SULF2
Proteoglycan biosynthetic process 0.76 0.01521 EXTL3, NDST1
Myeloid cell activation involved in immune response 0.78 0.01734 F2RL1, SBNO2
Glycosaminoglycan catabolic process 0.76 0.01789 HPSE, PGLYRP1
Cellular glucan metabolic process 0.75 0.03104 MGAM, PYGL
Glucan metabolic process 0.75 0.03104 MGAM, PYGL
Glomerular epithelial cell development 0.88 0.03312 IQGAP1
Positive regulation of mitochondrial fission 0.79 0.03312 PINK1
Manganese ion transport 0.73 0.03961 SLC11A1
Regulation of hair follicle development 0.78 0.04284 HPSE
Cellular polysaccharide metabolic process 0.72 0.04295 MGAM, PYGL
Nucleus localization 0.76 0.07144 TACC3
Glycogen catabolic process 0.88 0.08388 PYGL
Peptide cross-linking 0.74 0.09616 TGM3
Cell proliferation in forebrain 0.85 0.09616 TACC3
Regulation of CD4-positive, alpha-beta T cell activation -0.90 0.00485 CD55, CD83
Aminoglycan catabolic process -0.75 0.02074 HPSE, PGLYRP1
Regulation of oxidative phosphorylation -0.76 0.03312 PINK1
Nuclear pore organization -0.80 0.03637 TMEM33
Regulation of natural killer cell differentiation -0.71 0.03961 PGLYRP1
Pore complex assembly -0.72 0.03961 TMEM33
Glycoprotein catabolic process -0.77 0.04284 HPSE
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BMC Systems Biology

ISSN: 1752-0509

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