Fig. 2

The structure of the QSP model. Left panel: A three-compartment PK module was used to describe the reported pharmacokinetic data. The first compartment was the AC, the second compartment was plasma, and the third was ‘peripheral tissue’. Drug decay was assumed to occur in plasma and ‘peripheral tissue’ compartments. The rates of drug distribution and decay were described by the corresponding parameters. Right panel: The dynamics of Pneumocystis were described by a two-stage model which involves both trophic forms and asci. The temporal changes of trophic forms and asci were also controlled by the indicated parameters. The drug effects were indicated by arrows (promoting) and 489 lines with solid circle heads (inhibiting)