Fig. 3

The temporal simulations of the PK modules were consistent with diverse experimental data. The temporal simulations of the plasma concentrations of anidulafungin (a), caspofungin (b), micafungin (c) and SMX (d) were compared to relevant experimental data. The black dots and black solid curves represent the construction data and corresponding model simulations; the colored dots and colored dashed curves represent the validation data and corresponding simulations. The data sources were elaborated in Table 2a. The colors in each panel were used to indicate different administration methods and dosages. In a, blue, i.v. of 1 mg/kg; magenta, green and red, i.p. of 80 mg/kg, 20 mg/kg and 5 mg/kg respectively. In b, blue and magenta, i.v. of 0.5 mg/kg and 5 mg; red, cyan and green, i.p. of 1 mg/kg, 5 mg/kg and 80 mg/kg; In c, blue, red and green, i.v. of 0.32 mg/kg, 1 mg/kg and 3.2 mg/kg; cyan and magenta, i.p. of 5 mg/kg and 80 mg/kg; In d, blue, oral of 50 mg/kg