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BMC Systems Biology

Networks and information flow

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  1. Content type: Research article

    The complex interplay between viral replication and host immune response during infection remains poorly understood. While many viruses are known to employ anti-immune strategies to facilitate their replicatio...

    Authors: Jason E. McDermott, Hugh D. Mitchell, Lisa E. Gralinski, Amie J. Eisfeld, Laurence Josset, Armand Bankhead III, Gabriele Neumann, Susan C. Tilton, Alexandra Schäfer, Chengjun Li, Shufang Fan, Shannon McWeeney, Ralph S. Baric, Michael G. Katze and Katrina M. Waters

    Citation: BMC Systems Biology 2016 10:93

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  2. Content type: Research Article

    Identifying the gene regulatory networks governing the workings and identity of cells is one of the main challenges in understanding processes such as cellular differentiation, reprogramming or cancerogenesis....

    Authors: Maryam Nazarieh, Andreas Wiese, Thorsten Will, Mohamed Hamed and Volkhard Helms

    Citation: BMC Systems Biology 2016 10:88

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  3. Content type: Research article

    Phytohormone synergies and signaling interdependency are important topics in plant developmental biology. Physiological and genetic experimental evidence for phytohormone crosstalk has been accumulating and a ...

    Authors: Xun Yue, Xing Guo Li, Xin-Qi Gao, Xiang Yu Zhao, Yu Xiu Dong and Chao Zhou

    Citation: BMC Systems Biology 2016 10:87

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  4. Content type: Research Article

    Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role ...

    Authors: Simona Catozzi, Juan Pablo Di-Bella, Alejandra C. Ventura and Jacques-Alexandre Sepulchre

    Citation: BMC Systems Biology 2016 10:84

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  5. Content type: Research article

    Glioma differentiation therapy is a novel strategy that has been used to induce glioma cells to differentiate into glia-like cells. Although some advances in experimental methods for exploring the molecular me...

    Authors: Xiaoqiang Sun, Jiajun Zhang, Qi Zhao, Xing Chen, Wenbo Zhu, Guangmei Yan and Tianshou Zhou

    Citation: BMC Systems Biology 2016 10:73

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  6. Content type: Research article

    It has been found that microRNAs (miRNAs) can function as a regulatory factor across species. For example, food-derived plant miRNAs may pass through the gastrointestinal (GI) tract, enter into the plasma and ...

    Authors: Hao Zhang, Yanpu Li, Yuanning Liu, Haiming Liu, Hongyu Wang, Wen Jin, Yanmei Zhang, Chao Zhang and Dong Xu

    Citation: BMC Systems Biology 2016 10:60

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  7. Content type: Research article

    The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often address...

    Authors: Bin Du, Daniel C. Zielinski, Erol S. Kavvas, Andreas Dräger, Justin Tan, Zhen Zhang, Kayla E. Ruggiero, Garri A. Arzumanyan and Bernhard O. Palsson

    Citation: BMC Systems Biology 2016 10:40

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  8. Content type: Research Article

    Budding yeast, S. cerevisiae, has been used extensively as a model organism for studying cellular processes in evolutionarily distant species, including humans. However, different human tissues, while inheriti...

    Authors: Shahin Mohammadi, Baharak Saberidokht, Shankar Subramaniam and Ananth Grama

    Citation: BMC Systems Biology 2015 9:96

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  9. Content type: Research article

    Understanding the dynamics of stem cell differentiation processes at the molecular level is a central challenge in developmental biology and regenerative medicine. Although the dynamic behaviors of differentia...

    Authors: Tatsuya Ando, Ryuji Kato and Hiroyuki Honda

    Citation: BMC Systems Biology 2015 9:82

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  10. Content type: Research article

    There is growing evidence that many diseases develop, progress, and respond to therapy differently in men and women. This variability may manifest as a result of sex-specific structures in gene regulatory netw...

    Authors: Kimberly Glass, John Quackenbush, Edwin K Silverman, Bartolome Celli, Stephen I Rennard, Guo-Cheng Yuan and Dawn L DeMeo

    Citation: BMC Systems Biology 2014 8:118

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  11. Content type: Research article

    One of the central interests of Virology is the identification of host factors that contribute to virus infection. Despite tremendous efforts, the list of factors identified remains limited. With omics techniq...

    Authors: Gabriel Bosque, Abel Folch-Fortuny, Jesús Picó, Alberto Ferrer and Santiago F Elena

    Citation: BMC Systems Biology 2014 8:129

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2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    1233 Usage Factor

    Social Media Impact
    134 mentions