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BMC Systems Biology

Systems physiology, pharmacology and medicine

Section edited by Christina Chan

This section covers the analysis and modeling of complex systems to better understand humans and animal biology, in particular with regard to human health and disease.

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  1. Content type: Research article

    Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over ph...

    Authors: Michael A. Rowland, Edward J. Perkins and Michael L. Mayo

    Citation: BMC Systems Biology 2017 11:35

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  2. Content type: Research article

    Although renal fibrosis and inflammation have shown to be involved in the pathophysiology of obstructive nephropathies, molecular mechanisms underlying evolution of these processes remain undetermined. In an a...

    Authors: Theofilos Papadopoulos, Audrey Casemayou, Eric Neau, Benjamin Breuil, Cécile Caubet, Denis Calise, Barbara A. Thornhill, Magdalena Bachvarova, Julie Belliere, Robert L. Chevalier, Panagiotis Moulos, Dimcho Bachvarov, Benedicte Buffin-Meyer, Stéphane Decramer, Françoise Conte Auriol, Jean-Loup Bascands…

    Citation: BMC Systems Biology 2017 11:31

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  3. Content type: Research article

    We contrast the pectoralis muscle transcriptomes of broilers selected from within a single genetic line expressing divergent feed efficiency (FE) in an effort to improve our understanding of the mechanistic basis...

    Authors: Walter Bottje, Byung-Whi Kong, Antonio Reverter, Ashley J. Waardenberg, Kentu Lassiter and Nicholas J. Hudson

    Citation: BMC Systems Biology 2017 11:29

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  4. Content type: Research Article

    Clostridium difficile is a bacterium which can infect various animal species, including humans. Infection with this bacterium is a leading healthcare-associated illness. A better under...

    Authors: Sara Saheb Kashaf, Claudio Angione and Pietro Lió

    Citation: BMC Systems Biology 2017 11:25

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  5. Content type: Research Article

    Alzheimer disease (AD) is a progressive neurodegenerative disease that destroys memory and cognitive skills. AD is characterized by the presence of two types of neuropathological hallmarks: extracellular plaqu...

    Authors: Wenrui Hao and Avner Friedman

    Citation: BMC Systems Biology 2016 10:108

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  6. Content type: Research Article

    Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for partur...

    Authors: Douglas Brubaker, Alethea Barbaro, Mark R. Chance and Sam Mesiano

    Citation: BMC Systems Biology 2016 10:79

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  7. Content type: Research article

    Development of resistance against first line drug therapy including cisplatin and paclitaxel in high-grade serous ovarian cancer (HGSOC) presents a major challenge. Identifying drug candidates breaking resista...

    Authors: Peter Andorfer, Alexander Heuwieser, Andreas Heinzel, Arno Lukas, Bernd Mayer and Paul Perco

    Citation: BMC Systems Biology 2016 10:33

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  8. Content type: Research article

    The success of genome-scale models (GEMs) can be attributed to the high-quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional regulatory networks on an organism-specific basis...

    Authors: Elizabeth Brunk, Nathan Mih, Jonathan Monk, Zhen Zhang, Edward J. O’Brien, Spencer E. Bliven, Ke Chen, Roger L. Chang, Philip E. Bourne and Bernhard O. Palsson

    Citation: BMC Systems Biology 2016 10:26

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  9. Content type: Research article

    As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) is found in high levels in ALL cells. Neve...

    Authors: Eleftherios Ouzounoglou, Dimitra Dionysiou and Georgios S. Stamatakos

    Citation: BMC Systems Biology 2016 10:23

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  10. Content type: Research article

    The insulin-like growth factor (IGF) system impacts cellular development by regulating proliferation, differentiation, and apoptosis, and is an attractive therapeutic target in cancer. The IGF system is comple...

    Authors: Dan Tian, Isaiah Mitchell and Pamela K. Kreeger

    Citation: BMC Systems Biology 2016 10:15

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  11. Content type: Research article

    Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities. Incomplete knowledge of antibiotic and host immune dynamics in ...

    Authors: Elsje Pienaar, Véronique Dartois, Jennifer J. Linderman and Denise E. Kirschner

    Citation: BMC Systems Biology 2015 9:79

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  12. Content type: Research article

    Cytokine-hormone network deregulations underpin pathologies ranging from autoimmune disorders to cancer, but our understanding of these networks in physiological/pathophysiological states remains patchy. We em...

    Authors: Sarah L. Field, Tathagata Dasgupta, Michele Cummings, Richard S. Savage, Julius Adebayo, Hema McSara, Jeremy Gunawardena and Nicolas M. Orsi

    Citation: BMC Systems Biology 2015 9:76

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  13. Content type: Research article

    A hallmark of chronic liver disease is the impairment of the liver’s innate regenerative ability. In this work we use a computational approach to unravel the principles underlying control of liver repair follo...

    Authors: Daniel Cook, Babatunde A. Ogunnaike and Rajanikanth Vadigepalli

    Citation: BMC Systems Biology 2015 9:71

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  14. Content type: Research Article

    Methyltransferase (MT) reactions, in which methyl groups are attached to substrates, are fundamental to many aspects of cell biology and human physiology. The universal methyl donor for these reactions is S-ad...

    Authors: Michael C. Reed, Mary V. Gamble, Megan N. Hall and H. Frederik Nijhout

    Citation: BMC Systems Biology 2015 9:69

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  15. Content type: Research article

    The vascular endothelial growth factor (VEGF) family is central to cancer angiogenesis. However, targeting VEGF as an anti-cancer therapeutic approach has shown success for some tumor types but not others. Her...

    Authors: R. Joseph Bender and Feilim Mac Gabhann

    Citation: BMC Systems Biology 2015 9:55

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  16. Content type: Research article

    Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dos...

    Authors: Sibylle Schirm, Christoph Engel, Markus Loeffler and Markus Scholz

    Citation: BMC Systems Biology 2014 8:138

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  17. Content type: Research article

    Given the complex nature of cardiovascular disease (CVD), information derived from a systems-level will allow us to fully interrogate features of CVD to better understand disease pathogenesis and to identify n...

    Authors: Peng Li, Yingxue Fu, Jinlong Ru, Chao Huang, Jiangfeng Du, Chunli Zheng, Xuetong Chen, Pidong Li, Aiping Lu, Ling Yang and Yonghua Wang

    Citation: BMC Systems Biology 2014 8:141

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2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    1233 Usage Factor

    Social Media Impact
    134 mentions