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Systems physiology, pharmacology and medicine

Section edited by Christina Chan

This section covers the analysis and modeling of complex systems to better understand humans and animal biology, in particular with regard to human health and disease.

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  1. The relapsing-remitting dynamics is a hallmark of autoimmune diseases such as Multiple Sclerosis (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of a...

    Authors: Nieves Vélez de Mendizábal, Jorge Carneiro, Ricard V Solé, Joaquín Goñi, Jean Bragard, Ivan Martinez-Forero, Sara Martinez-Pasamar, Jorge Sepulcre, Javier Torrealdea, Francesca Bagnato, Jordi Garcia-Ojalvo and Pablo Villoslada
    Citation: BMC Systems Biology 2011 5:114
    Content type: Research article Published on:

  3. Integrated networks hold great promise in a variety of contexts. In a recent study, we have combined expression and interaction data to identify a putative network underlying early human organogenesis that con...

    Authors: Hai Fang, Wen Jin, Ying Yang, Ying Jin, Ji Zhang and Kankan Wang
    Citation: BMC Systems Biology 2011 5:108
    Content type: Research article Published on:

  4. Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to apply to the analysis of systems biology data (trans...

    Authors: Jurjen W Westra, Walter K Schlage, Brian P Frushour, Stephan Gebel, Natalie L Catlett, Wanjiang Han, Sean F Eddy, Arnd Hengstermann, Andrea L Matthews, Carole Mathis, Rosemarie B Lichtner, Carine Poussin, Marja Talikka, Emilija Veljkovic, Aaron A Van Hooser, Benjamin Wong…
    Citation: BMC Systems Biology 2011 5:105
    Content type: Methodology article Published on:

  5. MicroRNAs (miRNAs) are a class of endogenous, small and highly conserved noncoding RNAs that control gene expression either by degradation of target mRNAs or by inhibition of protein translation. They play imp...

    Authors: Chien-Wei Tseng, Chen-Ching Lin, Chiung-Nien Chen, Hsuan-Cheng Huang and Hsueh-Fen Juan
    Citation: BMC Systems Biology 2011 5:99
    Content type: Research article Published on:

  6. Cervical cancer is a major mortality factor in the female population. This neoplastic is an excellent model for studying the mechanisms involved in cancer maintenance, because the Human Papilloma Virus (HPV) i...

    Authors: Juan Carlos Higareda-Almaraz, María delRocío Enríquez-Gasca, Magdalena Hernández-Ortiz, Osbaldo Resendis-Antonio and Sergio Encarnación-Guevara
    Citation: BMC Systems Biology 2011 5:96
    Content type: Research article Published on:

  7. Protein-protein interaction networks and phenotype similarity information have been synthesized together to discover novel disease-causing genes. Genetic or phenotypic similarities are manifested as certain mo...

    Authors: Xin Yao, Han Hao, Yanda Li and Shao Li
    Citation: BMC Systems Biology 2011 5:79
    Content type: Research article Published on:

  9. Estrogens regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of gene expression. Transcription regulation upon estrog...

    Authors: Changyu Shen, Yiwen Huang, Yunlong Liu, Guohua Wang, Yuming Zhao, Zhiping Wang, Mingxiang Teng, Yadong Wang, David A Flockhart, Todd C Skaar, Pearlly Yan, Kenneth P Nephew, Tim HM Huang and Lang Li
    Citation: BMC Systems Biology 2011 5:67
    Content type: Research article Published on:

  10. The individual character of pharmacokinetics is of great importance in the risk assessment of new drug leads in pharmacological research. Amongst others, it is severely influenced by the properties and inter-i...

    Authors: Joachim Bucher, Stephan Riedmaier, Anke Schnabel, Katrin Marcus, Gabriele Vacun, Thomas S Weiss, Wolfgang E Thasler, Andreas K Nüssler, Ulrich M Zanger and Matthias Reuss
    Citation: BMC Systems Biology 2011 5:66
    Content type: Research article Published on:

  11. Endocrine disrupting chemicals (e.g., estrogens, androgens and their mimics) are known to affect reproduction in fish. 17α-ethynylestradiol is a synthetic estrogen used in birth control pills. 17β-trenbolone i...

    Authors: Zhenhong Li, Kevin J Kroll, Kathleen M Jensen, Daniel L Villeneuve, Gerald T Ankley, Jayne V Brian, María S Sepúlveda, Edward F Orlando, James M Lazorchak, Mitchell Kostich, Brandon Armstrong, Nancy D Denslow and Karen H Watanabe
    Citation: BMC Systems Biology 2011 5:63
    Content type: Research article Published on:

  12. Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst formation throughout the kidney parenchyma. It is caused by mutations in either of two genes, PKD1 and PKD2. Mice that lack functional...

    Authors: Priyanka Pandey, Shan Qin, Jacqueline Ho, Jing Zhou and Jordan A Kreidberg
    Citation: BMC Systems Biology 2011 5:56
    Content type: Research article Published on:

  13. Endothelial progenitor cells (EPCs) have been implicated in different processes crucial to vasculature repair, which may offer the basis for new therapeutic strategies in cardiovascular disease. Despite advanc...

    Authors: Francisco J Azuaje, Haiying Wang, Huiru Zheng, Frédérique Léonard, Magali Rolland-Turner, Lu Zhang, Yvan Devaux and Daniel R Wagner
    Citation: BMC Systems Biology 2011 5:46
    Content type: Research article Published on:

  14. Surprisal analysis is a thermodynamic-like molecular level approach that identifies biological constraints that prevents the entropy from reaching its maximum. To examine the significance of altered gene expre...

    Authors: Nataly Kravchenko-Balasha, F Remacle, Ayelet Gross, Varda Rotter, Alexander Levitzki and RD Levine
    Citation: BMC Systems Biology 2011 5:42
    Content type: Research article Published on:

  15. Cancer has remarkable complexity at the molecular level, with multiple genes, proteins, pathways and regulatory interconnections being affected. We introduce a systems biology approach to study cancer that for...

    Authors: Shivashankar H Nagaraj and Antonio Reverter
    Citation: BMC Systems Biology 2011 5:35
    Content type: Research article Published on:

BMC Systems Biology

ISSN: 1752-0509

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