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BMC Systems Biology

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  1. Content type: Methodology

    Positive semi-definiteness is a critical property in kernel methods for Support Vector Machine (SVM) by which efficient solutions can be guaranteed through convex quadratic programming. However, a lot of simil...

    Authors: Hao Jiang, Wai-Ki Ching, Yushan Qiu and Xiao-Qing Cheng

    Citation: BMC Systems Biology 2017 11(Suppl 6):115

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  2. Content type: Research

    Traditional drug identification methods follow the “one drug-one target” thought. But those methods ignore the natural characters of human diseases. To overcome this limitation, many identification methods of ...

    Authors: Jin-Xing Liu, Dong-Qin Wang, Chun-Hou Zheng, Ying-Lian Gao, Sha-Sha Wu and Jun-Liang Shang

    Citation: BMC Systems Biology 2017 11(Suppl 6):119

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  3. Content type: Research

    Mining frequent gene regulation sequential patterns in time course microarray datasets is an important mining task in bioinformatics. Although finding such patterns are of paramount important for studying a di...

    Authors: Morteza Zihayat, Heidar Davoudi and Aijun An

    Citation: BMC Systems Biology 2017 11(Suppl 6):109

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  4. Content type: Research

    Drug side effects are one of main concerns in the drug discovery, which gains wide attentions. Investigating drug side effects is of great importance, and the computational prediction can help to guide wet exp...

    Authors: Wen Zhang, Xiang Yue, Feng Liu, Yanlin Chen, Shikui Tu and Xining Zhang

    Citation: BMC Systems Biology 2017 11(Suppl 6):101

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  5. Content type: Methodology

    Probabilistic Boolean networks (PBNs) have been proposed for analyzing external control in gene regulatory networks with incorporation of uncertainty. A context-sensitive PBN with perturbation (CS-PBNp), exten...

    Authors: Ou Wei, Zonghao Guo, Yun Niu and Wenyuan Liao

    Citation: BMC Systems Biology 2017 11(Suppl 6):104

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  6. Content type: Research Article

    Specific cellular states are often associated with distinct gene expression patterns. These states are plastic, changing during development, or in the transition from health to disease. One relatively simple e...

    Authors: Daniel Schlauch, Kimberly Glass, Craig P. Hersh, Edwin K. Silverman and John Quackenbush

    Citation: BMC Systems Biology 2017 11:139

    Published on:

  7. Content type: Methodology Article

    Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tiss...

    Authors: Justin Caccavale, David Fiumara, Michael Stapf, Liedeke Sweitzer, Hannah J. Anderson, Jonathan Gorky, Prasad Dhurjati and Deni S. Galileo

    Citation: BMC Systems Biology 2017 11:124

    Published on:

  8. Content type: Methodology Article

    State-of-the-art strain engineering techniques for the host Pichia pastoris (syn. Komagataella spp.) include overexpression of homologous and heterologous genes, and deletion of host genes. For metabolic and cell...

    Authors: Roland Prielhofer, Juan J. Barrero, Stefanie Steuer, Thomas Gassler, Richard Zahrl, Kristin Baumann, Michael Sauer, Diethard Mattanovich, Brigitte Gasser and Hans Marx

    Citation: BMC Systems Biology 2017 11:123

    Published on:

  9. Content type: Research Article

    Cellular behaviors are governed by interaction networks among biomolecules, for example gene regulatory and signal transduction networks. An often used dynamic modeling framework for these networks, Boolean mo...

    Authors: Parul Maheshwari and Réka Albert

    Citation: BMC Systems Biology 2017 11:122

    Published on:

  10. Content type: Research Article

    Polygenic diseases are usually caused by the dysfunction of multiple genes. Unravelling such disease genes is crucial to fully understand the genetic landscape of diseases on molecular level. With the advent o...

    Authors: Limei Lin, Tinghong Yang, Ling Fang, Jian Yang, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:121

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  11. Content type: Research Article

    In favorable conditions bacterial doubling time is less than 20 min, shorter than DNA replication time. In E. coli a single round of genome replication lasts about 40 min and it must be accomplished about 20 min ...

    Authors: Joanna Jaruszewicz-Błońska and Tomasz Lipniacki

    Citation: BMC Systems Biology 2017 11:117

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  12. Content type: Research Article

    Models that incorporate specific chemical mechanisms have been successful in describing the activity of Drosophila developmental enhancers as a function of underlying transcription factor binding motifs. Despite ...

    Authors: Kenneth A. Barr, Carlos Martinez, Jennifer R. Moran, Ah-Ram Kim, Alexandre F. Ramos and John Reinitz

    Citation: BMC Systems Biology 2017 11:116

    Published on:

  13. Content type: Research Article

    The complexity of metabolic networks can make the origin and impact of changes in central metabolism occurring during diseases difficult to understand. Computer simulations can help unravel this complexity, an...

    Authors: Anthony C. Smith, Filmon Eyassu, Jean-Pierre Mazat and Alan J. Robinson

    Citation: BMC Systems Biology 2017 11:114

    Published on:

  14. Content type: Research Article

    Particle size is a key parameter for drug-delivery nanoparticle design. It is believed that the size of a nanoparticle may have important effects on its ability to overcome the transport barriers in biological...

    Authors: Mohammad Aminul Islam, Sutapa Barua and Dipak Barua

    Citation: BMC Systems Biology 2017 11:113

    Published on:

  15. Content type: Research Article

    The pursuit of standardization and reliability in synthetic biology has achieved, in recent years, a number of advances in the design of more predictable genetic parts for biological circuits. However, even wi...

    Authors: S. Cardinale and G. Cambray

    Citation: BMC Systems Biology 2017 11:112

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  16. Content type: Research Article

    Helicobacter Pylori (HP) is the most common risk factor for gastric cancer. Nearly half the world’s population is infected with HP, but only a small percentage of those develop significant pathology. The bacte...

    Authors: Richard Ballweg, Frederick Schozer, Kelsey Elliott, Alexander Kuhn, Logan Spotts, Eitaro Aihara and Tongli Zhang

    Citation: BMC Systems Biology 2017 11:111

    Published on:

  17. Content type: Research Article

    The recent development of single-cell transcriptomics has enabled gene expression to be measured in individual cells instead of being population-averaged. Despite this considerable precision improvement, infer...

    Authors: Ulysse Herbach, Arnaud Bonnaffoux, Thibault Espinasse and Olivier Gandrillon

    Citation: BMC Systems Biology 2017 11:105

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  18. Content type: Research Article

    Up to date, Mycobacterium tuberculosis (Mtb) remains as the worst intracellular killer pathogen. To establish infection, inside the granuloma, Mtb reprograms its metabolism to support both growth and survival, ke...

    Authors: Víctor A. López-Agudelo, Andres Baena, Howard Ramirez-Malule, Silvia Ochoa, Luis F. Barrera and Rigoberto Ríos-Estepa

    Citation: BMC Systems Biology 2017 11:107

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  19. Content type: Research Article

    Drug resistance mediated by P-glycoprotein (P-gp) renders many cancer therapies ineffective. One P-gp substrate is the widely used chemotherapy drug paclitaxel. Co-administration of paclitaxel and another drug...

    Authors: Joe Bender, Jianwen Fang and Richard Simon

    Citation: BMC Systems Biology 2017 11:108

    Published on:

  20. Content type: Research Article

    Vitiligo is a long-term skin disease characterized by the loss of pigment in the skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms of Vernonia anthelmintica (L.) remain a...

    Authors: Ji Ye Wang, Hong Chen, Yin Yin Wang, Xiao Qin Wang, Han Ying Chen, Mei Zhang, Yun Tang and Bo Zhang

    Citation: BMC Systems Biology 2017 11:103

    Published on:

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2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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