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  1. Content type: Research

    Alzheimer’s disease (AD) is a progressive neurological disorder, recognized as the most common cause of dementia affecting people aged 65 and above. AD is characterized by an increase in amyloid metabolism, an...

    Authors: Bobby Ranjan, Ket Hing Chong and Jie Zheng

    Citation: BMC Systems Biology 2018 12(Suppl 1):10

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  2. Content type: Research

    A network motif is a sub-network that occurs frequently in a given network. Detection of such motifs is important since they uncover functions and local properties of the given biological network. Finding moti...

    Authors: Kingshuk Mukherjee, Md Mahmudul Hasan, Christina Boucher and Tamer Kahveci

    Citation: BMC Systems Biology 2018 12(Suppl 1):6

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  3. Content type: Research

    Time course measurement of single molecules on a cell surface provides detailed information about the dynamics of the molecules that would otherwise be inaccessible. To extract the quantitative information, si...

    Authors: Shunsuke Teraguchi and Yutaro Kumagai

    Citation: BMC Systems Biology 2018 12(Suppl 1):15

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  4. Content type: Research article

    Cell death as a result of ischemic injury triggers powerful mechanisms regulated by germline-encoded Pattern Recognition Receptors (PRRs) with shared specificity that recognize invading pathogens and endogenou...

    Authors: Elena Dimitrova, Leslie A. Caromile, Reinhard Laubenbacher and Linda H. Shapiro

    Citation: BMC Systems Biology 2018 12:50

    Published on:

  5. Content type: Research article

    Controlling complex molecular regulatory networks is getting a growing attention as it can provide a systematic way of driving any cellular state to a desired cell phenotypic state. A number of recent studies ...

    Authors: Sang-Mok Choo, Byunghyun Ban, Jae Il Joo and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2018 12:49

    Published on:

  6. Content type: Research Article

    Kinase inhibition in the mitogen activated protein kinase (MAPK) pathway is a standard therapy for cancer patients with activating BRAF mutations. However, the anti-tumorigenic effect and clinical benefit are ...

    Authors: Helma Zecena, Daniel Tveit, Zi Wang, Ahmed Farhat, Parvita Panchal, Jing Liu, Simar J. Singh, Amandeep Sanghera, Ajay Bainiwal, Shuan Y. Teo, Frank L. Meyskens Jr, Feng Liu-Smith and Fabian V. Filipp

    Citation: BMC Systems Biology 2018 12:33

    Published on:

  7. Content type: Research article

    Progesterone plays an essential role in mammalian ovulation. Although much is known about this process, the gene networks involved in ovulation have yet to be established. When analyze the mechanisms of ovulat...

    Authors: Fang Yang, Meng Wang, Baoyun Zhang, Wei Xiang, Ke Zhang, Mingxin Chu and Pingqing Wang

    Citation: BMC Systems Biology 2018 12:36

    Published on:

  8. Content type: Research article

    Existing experimental data have shown hypoxia to be an important factor affecting the proliferation of mesenchymal stromal cells (MSCs), but the contrasting observations made at various hypoxic levels raise th...

    Authors: Bo Zhang, Hua Ye and Aidong Yang

    Citation: BMC Systems Biology 2018 12:35

    Published on:

  9. Content type: Research article

    Melanoma can be diagnosed by identifying nests of cells on the skin surface. Understanding the processes that drive nest formation is important as these processes could be potential targets for new cancer drug...

    Authors: Parvathi Haridas, Alexander P. Browning, Jacqui A. McGovern, D. L. Sean McElwain and Matthew J. Simpson

    Citation: BMC Systems Biology 2018 12:34

    Published on:

  10. Content type: Research

    The integration of gene expression profiles (GEPs) and large-scale biological networks derived from pathways databases is a subject which is being widely explored. Existing methods are based on network distanc...

    Authors: Bertrand Miannay, Stéphane Minvielle, Florence Magrangeas and Carito Guziolowski

    Citation: BMC Systems Biology 2018 12(Suppl 3):32

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  11. Content type: Research

    Expression-based phenotype classification using either microarray or RNA-Seq measurements suffers from a lack of specificity because pathway timing is not revealed and expressions are averaged across groups of...

    Authors: Alireza Karbalayghareh, Ulisses Braga-Neto and Edward R. Dougherty

    Citation: BMC Systems Biology 2018 12(Suppl 3):23

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  12. Content type: Research

    Decomposing a protein-protein interaction network (PPI network) into non-overlapping clusters or communities, sometimes called “network modules,” is an important way to explore functional roles of sets of gene...

    Authors: Sarah Hall-Swan, Jake Crawford, Rebecca Newman and Lenore J. Cowen

    Citation: BMC Systems Biology 2018 12(Suppl 3):24

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  13. Content type: Software

    The 16S rRNA gene-based amplicon sequencing analysis is widely used to determine the taxonomic composition of microbial communities. Once the taxonomic composition of each community is obtained, evolutionary r...

    Authors: Hiroshi Mori, Takayuki Maruyama, Masahiro Yano, Takuji Yamada and Ken Kurokawa

    Citation: BMC Systems Biology 2018 12(Suppl 2):30

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  14. Content type: Research

    Transcriptomic datasets often contain undeclared heterogeneity arising from biological variation such as diversity of disease subtypes, treatment subgroups, time-series gene expression, nested experimental con...

    Authors: Abha Belorkar, Rajanikanth Vadigepalli and Limsoon Wong

    Citation: BMC Systems Biology 2018 12(Suppl 2):28

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  15. Content type: Research

    Recently, there have been several attempts to produce long-chain dicarboxylic acids (DCAs) in various microbial hosts. Of these, Yarrowia lipolytica has great potential due to its oleaginous characteristics and u...

    Authors: Pranjul Mishra, Na-Rae Lee, Meiyappan Lakshmanan, Minsuk Kim, Byung-Gee Kim and Dong-Yup Lee

    Citation: BMC Systems Biology 2018 12(Suppl 2):12

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  16. Content type: Research

    Identifying gene regulatory networks is an important task for understanding biological systems. Time-course measurement data became a valuable resource for inferring gene regulatory networks. Various methods h...

    Authors: Sungjoon Park, Jung Min Kim, Wonho Shin, Sung Won Han, Minji Jeon, Hyun Jin Jang, Ik-Soon Jang and Jaewoo Kang

    Citation: BMC Systems Biology 2018 12(Suppl 2):20

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  17. Content type: Research

    Regeneration is an important biological process for the restoration of organ mass, structure, and function after damage, and involves complex bio-physiological mechanisms including cell differentiation and imm...

    Authors: Fang-Yu Liu, Te-Cheng Hsu, Patrick Choong, Min-Hsuan Lin, Yung-Jen Chuang, Bor-Sen Chen and Che Lin

    Citation: BMC Systems Biology 2018 12(Suppl 2):29

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  18. Content type: Research

    One of the crucial steps toward understanding the associations among molecular interactions, pathways, and diseases in a cell is to investigate detailed atomic protein-protein interactions (PPIs) in the struct...

    Authors: Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yu-Yao Tseng and Jinn-Moon Yang

    Citation: BMC Systems Biology 2018 12(Suppl 2):13

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  19. Content type: Research

    Ginseng is a popular traditional herbal medicine in north-eastern Asia. It has been used for human health for over thousands of years. With the rise in global temperature, the production of Korean ginseng (Pan...

    Authors: Inuk Jung, Hyejin Kang, Jang Uk Kim, Hyeonsook Chang, Sun Kim and Woosuk Jung

    Citation: BMC Systems Biology 2018 12(Suppl 2):27

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  20. Content type: Research

    With the rapid advancement of array-based genotyping techniques, genome-wide association studies (GWAS) have successfully identified common genetic variants associated with common complex diseases. However, it...

    Authors: Minseok Kwon, Sangseob Leem, Joon Yoon and Taesung Park

    Citation: BMC Systems Biology 2018 12(Suppl 2):19

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  21. Content type: Research

    Cell surface proteins have provided useful targets and biomarkers for advanced cancer therapies. The recent clinical success of antibody-drug conjugates (ADCs) highlights the importance of finding selective su...

    Authors: Yourae Hong, Choa Park, Nayoung Kim, Juyeon Cho, Sung Ung Moon, Jongmin Kim, Euna Jeong and Sukjoon Yoon

    Citation: BMC Systems Biology 2018 12(Suppl 2):17

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  22. Content type: Research

    Drug combination therapy, which is considered as an alternative to single drug therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug combination therapies are widely u...

    Authors: Minji Jeon, Sunkyu Kim, Sungjoon Park, Heewon Lee and Jaewoo Kang

    Citation: BMC Systems Biology 2018 12(Suppl 2):16

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  23. Content type: Research

    Gene Ontology (GO) is one of the most popular bioinformatics resources. In the past decade, Gene Ontology-based gene semantic similarity has been effectively used to model gene-to-gene interactions in multiple...

    Authors: Jiajie Peng, Xuanshuo Zhang, Weiwei Hui, Junya Lu, Qianqian Li, Shuhui Liu and Xuequn Shang

    Citation: BMC Systems Biology 2018 12(Suppl 2):18

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  24. Content type: Review Article

    Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “o...

    Authors: James T. Yurkovich, Aarash Bordbar, Ólafur E. Sigurjónsson and Bernhard O. Palsson

    Citation: BMC Systems Biology 2018 12:31

    Published on:

  25. Content type: Research Article

    Muscle atrophy, an involuntary loss of muscle mass, is involved in various diseases and sometimes leads to mortality. However, therapeutics for muscle atrophy thus far have had limited effects. Here, we presen...

    Authors: Jinmyung Jung, Mijin Kwon, Sunghwa Bae, Soorin Yim and Doheon Lee

    Citation: BMC Systems Biology 2018 12:26

    Published on:

Page 2 of 78

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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