Featured article: Modelling Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia, currently affecting approximately 44 million people world-wide. This model of partial differential equations is used to simulate the effect of drugs currently undergoing clinical trials and to suggest a combination of therapies capable of slowing the progression of AD.

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  1. Database

    A comprehensive map of the influenza A virus replication cycle

    Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka

    Published on: 2 October 2013

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Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.


  • Alexandros Houssein, BioMed Central

Section Editors

  • Nitin Baliga, Institute for Systems Biology
  • Christina Chan, Michigan State University
  • Luonan Chen, Chinese Academy of Sciences
  • Sang Yup Lee, Korea Advanced Institute of Science and Technology
  • Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
  • Matteo Pellegrini, University of California, Los Angeles

Model of the month

From BioModels at EMBL-EBI

November 2016 by Nick Juty

An integrated dynamic model of eukaryotic osmolyte system, linking signaling with regulation of gene expression, metabolic control and growth.

Read more about the model here