Featured article: Multiple-signal processing synthetic circuits

Figure 2 Revised

Constructing artificial genetic circuits and systems that have good programmability and controllability is a major challenge in the synthetic biology community. Towards this end, this article proposes the construction of light and chemical-signal processing synthetic mammalian circuits, as a means of producing predictable cellular responses.

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  1. Research article

    Coordinated regulation of acid resistance in Escherichia coli

    Patricia Aquino, Brent Honda, Suma Jaini, Anna Lyubetskaya, Krutika Hosur, Joanna G. Chiu, Iriny Ekladious, Dongjian Hu, Lin Jin, Marianna K. Sayeg, Arion I. Stettner, Julia Wang, Brandon G. Wong, Winnie S. Wong, Stephen L. Alexander, Cong Ba…

    Published on: 6 January 2017

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  1. Database

    A comprehensive map of the influenza A virus replication cycle

    Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka

    Published on: 2 October 2013

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Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses, integration of different levels of information and synthetic biology.


  • Alexandros Houssein, BioMed Central

Section Editors

  • Nitin Baliga, Institute for Systems Biology
  • Christina Chan, Michigan State University
  • Luonan Chen, Chinese Academy of Sciences
  • Sang Yup Lee, Korea Advanced Institute of Science and Technology
  • Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
  • Matteo Pellegrini, University of California, Los Angeles

Model of the month

From BioModels at EMBL-EBI

January 2017 by Thawfeek Mohamed Varusai 

New Content Item

Key molecular interactions and intricate dynamic properties of the Ring1B/Bmi1/H2A ubiquitination network studied using a mathematical model, revealed oscillatory, bistable and excitable behaviours.

Read more about the model here