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Most Accessed Articles: BMC Systems Biologyhttp://bmcsystbiol.biomedcentral.comMost Accessed Articles: BMC Systems BiologyTracing regulatory routes in metabolism using generalised supply-demand analysis supply-demand analysis is a conceptual framework that views metabolism as a molecular economy. Metabolic pathways are partitioned into so-called supply and demand blocks that produce and consume a ...Thu, 03 Dec 2015 00:00:00 GMT D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer2015-12-03T00:00:00ZSystematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis C4 photosynthetic cycle supercharges photosynthesis by concentrating CO2 around ribulose-1,5-bisphosphate carboxylase and significantly reduces the oxygenation reaction. Therefore engineering C4 feature into ...Wed, 12 Dec 2012 00:00:00 GMT Wang, Longyun Guo, Yixue Li and Zhuo Wang2012-12-12T00:00:00ZA comprehensive map of the influenza A virus replication cycle is a common infectious disease caused by influenza viruses. Annual epidemics cause severe illnesses, deaths, and economic loss around the world. To better defend against influenza viral infection, it...Wed, 02 Oct 2013 00:00:00 GMT Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka2013-10-02T00:00:00ZA model comparison study of the flowering time regulatory network in Arabidopsis dynamic models of a gene regulatory network of the light-induced floral transition process in Arabidopsis have been developed to capture the behavior of gene transcription and infer predictions based on e...Tue, 11 Feb 2014 00:00:00 GMT CN Wang, Pei-Chun Chang, Ka-Lok Ng, Chun-Ming Chang, Phillip CY Sheu and Jeffrey JP Tsai2014-02-11T00:00:00ZiSVP: an integrated structural variant calling pipeline from high-throughput sequencing data variations (SVs), such as insertions, deletions, inversions, and duplications, are a common feature in human genomes, and a number of studies have reported that such SVs are associated with human di...Fri, 13 Dec 2013 00:00:00 GMT Mimori, Naoki Nariai, Kaname Kojima, Mamoru Takahashi, Akira Ono, Yukuto Sato, Yumi Yamaguchi-Kabata and Masao Nagasaki2013-12-13T00:00:00Z

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Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modeling, quantitative analyses and the integration of different levels of information.

Section Editors

  • Nitin Baliga, Institute for Systems Biology
  • Christina Chan, Michigan State University
  • Luonan Chen, Chinese Academy of Sciences
  • Sang Yup Lee, Korea Advanced Institute of Science and Technology
  • Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
  • Matteo Pellegrini, University of California, Los Angeles

Executive Editor

  • Tim Sands, BioMed Central

Model of the Month

From BioModels at EMBL-EBI

April 2016, selected by Thawfeek Mohamed Varusai

© From V Raia et al, Cancer Research 2011

The JAK/STAT signalling pathway is hyper-activated in several lymphomas. Here, the conditions prevailing the two types of lyphomas (PMBL and cHL) has been described using a mathematical model, and signalling components in the JAK/STAT pathway that can be a potential drug target has been identified and validated experimentally.

Read more about the model here