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Table 2 Enriched gene sets identified by GSEA analysis

From: A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Gene Sets

SIZE

NES

NOM p-val

Electron Transport Chain

43

-1.998

0.000

Fatty acid metabolism

33

-1.824

0.000

Glycolysis

55

-1.765

0.000

Oxidative Phosphorylation

30

-1.890

0.004

ROS

26

-1.741

0.009

PPP pathway

15

-1.644

0.010

Cell death

15

-1.631

0.010

ERK pathway

31

-1.620

0.016

Fatty acids beta-oxidation

7

-1.580

0.020

Fatty acid biosynthesis

5

-1.574

0.021

TCA

15

-1.631

0.023

Fructose

19

-1.599

0.026

ERK1 Erk2 Mapk pathway

29

-1.542

0.034

Glutathione

23

-1.520

0.036

Mitochondria

229

-1.945

0.002

  1. Size: number of genes in the gene set; NES: normalized enrichment score; NOM p-val: nominal P value.