From: Essential operating principles for tumor spheroid growth
Parameter | Maximum size | Viable rim width | Quiescence onset | Necrosis onset | Growth rate | Doubling time | Stability | Necrotic core size |
---|---|---|---|---|---|---|---|---|
DiffusionRate | ↑ | ↑ | ↑ | ↑ | -- | -- | ↔ | ↔ |
initialVal | ↑ | ↑ | ↑ | ↑ | ↓ | ↓ | ↔ | ↑ |
proConsumeRate | ↓ | ↓ | ↓ | ↓ | -- | -- | -- | ↔ |
quiConsumeRate | ↓ | ↓ | -- | ↔ | -- | -- | -- | ↔ |
prolifDelay | ↔ | -- | ↑ | ↑ | ↓ | ↓ | -- | ↔ |
removeDelay | ↑ | -- | -- | -- | -- | -- | ↔ | ↑ |
proNut | ↔/-- | -- | ↓ | ↓ | -- | -- | ↓ | ↔ |
quiNut | ↓ | ↓ | -- | ↓ | ↓ | -- | -- | --/↓ |
proBias | ↓ | ↑ | ↑ | ↑ | ↓ | ↓ | --/↑ | ↓ |
moveEmptyBias | ↔ | ↓/↑ | -- | -- | ↑ | -- | ↑ | ↑ |