Figure 5

The MAPK network model according to BioModel (id BIOMD28). The molecular species are labeled with integer numbers. Reactions are labeled with variables representing the corresponding reaction rate, b _i for binding rates, u _i for unbinding rates, and k _i for rates of first order reactions. Solid arrows in this figure represent binding reactions, and empty arrows for unbinding reactions. The parameter values of this model are taken as is from the SBML model. We have: b₁ = 0.005, b₃ = 0.025, b₅ = 0.05, b₇ = 0.005, b₉ = 0.045, b₁₀ = 0.01, b₁₁ = 0.01, b₁₂ = 0.0011, b₁₃ = 0.01, b₁₄ = 0.0018, u_{1,3,5,7,9,10,11,13} = 1, u₂ = 1.08, u₄ = 0.007, u₆ = 0.008, u₈ = 0.45, u₁₂ = 0.086, u₁₄ = 0.14, k₁ = 0.092, k₂ = 0.5, and k₃ = 0.47.