Table 1 Conditions on initial values for steady-states. Assuming that the initial number of receptors is higher than the combined capacity of both pathways (R0 > CDE0 + CIE0), low and high EGF-stimulations lead to two different steady-states, respectively. In steady-state I, the receptor internalizes primarily via CDE, whereas in steady-state II it is equally partitioned between CDE and CIE.
From: An ultrasensitive sorting mechanism for EGF Receptor Endocytosis
Initial values | Steady-state | CIE-internalization |
|---|---|---|
EGF0 < CDE0 | I | low |
CDE0 + CIE0 < EGF0 | II | high |