Figure 1From: Mathematical modeling and analysis of insulin clearance in vivoInsulin receptor activation in hepatocytes. The receptor is denoted as R. One or two insulin molecules can bind to the receptor (green arrows). This is indicated by a prefix I or I 2, respectively. Receptor phosphorylation (blue arrows) is indicated by a suffix p, receptor internalization to the endosomal compartment (red arrows) is indicated by a subscript en. Arrows with two heads indicate reversible reactions. Arrows with one head indicate irreversible reactions. Filled arrowheads indicate positive direction of rates.Back to article page