A computational analysis of protein-protein interaction networks in neurodegenerative diseases

BMC Systems Biology

Table 1 Network measurements for the four disease networks.

		MS-blood		AD-blood		MS-brain		AD-brain
Symbol	Description	full	giant comp	full	giant comp	full	giant comp	full	giant comp
N	number of nodes	205	180	96	82	148	109	134	84
<k>	average degree	3.77	4.08	5.1	5.63	3.12	3.59	2.85	3.31
<C>	clustering coefficient	0.32	0.35	0.43	0.44	0.26	0.29	0.32	0.35
D	diameter	-	14	-	12	-	13	-	11
mspl	mean shortest path length	-	4.76	-	5.5	-	4.6	-	5.41

The number of nodes, average degree (<k>), clustering coefficient (<C>), diameter of the network (D) and mean shortest path length (mspl) are shown for the overall networks (full) or for the giant component of each network (by considering only the nodes linked to the bigger subnetwork). The four networks analyzed are the MS in blood tissue (MS-blood); AD in blood tissue (AD-blood), MS in brain tissue (MS-brain) and the AD in brain tissue (AD-brain).

ISSN: 1752-0509