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Table 2 Truth table of all 16 events in the sample space of comparisons of individual interaction of protein i and protein j between HeLa and normal cells

From: Construction of a cancer-perturbed protein-protein interaction network for discovery of apoptosis drug targets

AIC detection results in HeLa cells

AIC detection results in normal cells

Comparisons between HeLa and normal cells

Target protein i

Target protein j

'AND' results

Target protein i

Target protein j

'AND' results

 

0

0

0

0

0

0

 

0

0

0

0

1

0

 

0

0

0

1

0

0

 

0

0

0

1

1

1

Loss-of-function

0

1

0

0

0

0

 

0

1

0

0

1

0

 

0

1

0

1

0

0

 

0

1

0

1

1

1

Loss-of-function

1

0

0

0

0

0

 

1

0

0

0

1

0

 

1

0

0

1

0

0

 

1

0

0

1

1

1

Loss-of-function

1

1

1

0

0

0

Gain-of-function

1

1

1

0

1

0

Gain-of-function

1

1

1

1

0

0

Gain-of-function

1

1

1

1

1

1

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