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Table 5 Different transient responses of the MAPK network

From: Dynamical pathway analysis

 

BRAF to MAP2K2

BRAF to MAPK1

Wild type

RiseTime: 31.5

RiseTime: 0.26

 

SettlingTime: 56.5

SettlingTime: 76.1

 

Overshoot: 0

Overshoot: 440.4

R73A Mutant

RiseTime: 2.6

RiseTime: 8.2

 

SettlingTime: 5.8

SettlingTime: 17.0

 

Overshoot: 0

Overshoot: 0

R80A Mutant

RiseTime: 11.7

RiseTime: 48.5

 

SettlingTime: 21.7

SettlingTime: 90.2

 

Overshoot: 0

Overshoot: 0