Figure 6
From: Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network
Simulated dynamic acyl-CoA concentration during fasting. (A, B) Dynamic change of simulated concentrations of acyl-CoA of different carbon chain length in healthy controls following a 20% increase of palmitoyl-CoA (C16) concentration. Concentration values were shifted in terms of their minima and normalized with respect to their maximum change resulting in normalized concentration values between 0 and 1. After 4 hours almost all acyl-CoAs reached their new steady-state values. (C, D) A 20% increase needs much longer (10 days) to attain the steady-state in the MCAD deficiency simulation.