Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation

BMC Systems Biology

Table 2 Top 15 enriched transcription factor binding sites

TF Name	Biological Process	Functional Category	Reference
1) C/EBPα	Acute myeloid leukemia	Tumor Progression	[63]
2) HLF	Acute lymphoblastic leukemia	Tumor Progression	[67]
3) PAX6	Eye development	Development	[90]
4) TAL1/SCL	Lymphocytic leukemia	Tumor Progression	[91]
5) HOXA4	Chronic lymphocytic leukemia	Tumor Progression	[73]
6) CDP/CUTL1	Mediate cell cycle progression	Cell Cycle	[92]
7) AML/RUNX1	Acute myeloid leukemia	Tumor Progression	[93]
8) TBP	Required for RNA Pol II	General Transcription	[94]
9) MEIS1	Acute myeloid leukemia	Tumor Progression	[79]
10) OCT-1/POU2F1	Regulates cyclin D1 w/STAT5	Cell Cycle	[95]
11) RAR-RXR	Acute promyelocytic leukemia	Tumor Progression	[81]
12) POU3F2	Neuronal development	Development	[96]
13) FOXO4/AFX	Mixed lineage leukemia	Tumor Progression	[82]
14) SOX9	Chondrogenesis	Development	[97]
15) POU1F1	Pituitary hormone secretion	Development	[98]

This table contains the top 15 enriched transcription factors binding sites found in the promoters of divergent genes, with literature references that link these factors to general functional categories of tumor progression, cell cycle, and development. The first column includes the transcription factor name. The second column contains the biological processes with which these factors are associated. The third column lists the general functional categories of these factors. The fourth column points to the literature references for these factors.

ISSN: 1752-0509