Figure 3

Simulations of the NGF receptor system. This chart contains simulation traces from various NGF receptor system models. The x-axis represents time in minutes whilst the y-axis represents the concentration of active ERK in molecules/cell. The blue line represents the simulated level of active ERK from the original Brown NGF model with both the Ras and Rap1 pathway patches, whilst the red line represents simulated active ERK with only the Rap1 pathway patch, and the green line represents simulated active ERK levels with only the Ras feedback patch. As can be seen, the Rap1 pathway patch is required to achieve a sustained ERK signal as the Ras pathway patch alone is only capable of producing a transient signal.