Figure 1

Unsupervised Hierarchical Cluster of Phenotypes by Pathways. Genes associated with a particular phenotype were evaluated for enrichment in KEGG pathways using SEPEA. P-values for KEGG pathway enrichment were then clustered using Spearman rank correlation in Cluster and the graphic was prepared using TreeView [73], where color ranges linearly from blue (p = 1) to orange (p = 0). Phenotype-gene relationships were downloaded from the Genetic Association Database [1] in June 2007 and phenotypes were further grouped according to Additional file 1. Request the TreeView file of this cluster from Julia Gohlke gohlkej@niehs.nih.gov for more detailed exploration.