Modeling metabolic networks in C. glutamicum: a comparison of rate laws in combination with various parameter optimization strategies

Table 1 The reaction system in more detail

No	Reaction	Enzyme	Inhibitor
R ₁	2 Pyr → AcLac + CO₂	AHAS	Val
R ₂	AcLac + NADPH₂ ⇌ DHIV + NADP⁺	AHAIR	Val
R ₃	DHIV → KIV + H₂O	DHAD	Val
R ₄	KIV + Glut → Val + α KG	BCAAT_ValB
R ₅	KIV + Ala → Val + Pyr	BCAAT_ValC
R ₆	Val → Val_ext	Trans_Val	Leu
R ₇	KIV + AcCoA → IPM + CoA	IPMS	Leu
R ₈	IPM + NAD⁺ → KIC + NADH₂ + CO₂	IPMDH
R ₉	KIC + Glut ⇌ Leu + α KG	BCAAT_LeuB
R ₁₀	Leu → Leu_ext	Trans_Leu	Val

The reactions in KEGG are lumped together resulting in this reaction scheme which is in accordance with META CYC except for the question of irreversibility, and apart from R₂ and R₉, which are reversible.

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