Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

BMC Systems Biology

Table 2 Metabolite exchanges between parasite and host: prediction vs. experiment

Metabolite	Predicted	Experiment	Comment	References
Glucose	Uptake	uptake		[57, 128, 129]
Lactate	Secretion	secretion		[57, 128, 129]
Hemoglobin	uptake	uptake		[57, 128]
Amino acids	Secretion	secretion		[57, 128, 129]
Isoleucine	uptake	uptake		[57, 128, 129]
Nucleosides/nucleobases	uptake	uptake		[128–130]
Choline	uptake	uptake		[68, 128, 129, 131]
Ethanolamine	almost no exchange	uptake	No gene assigned to ethanolamine transporter	[128, 132]
Phosphatidylethanolamine	uptake	uptake		[128, 132]
Phosphatidylserine	uptake	uptake		[128]
Phosphate	uptake	uptake		[64, 128, 129]
Pantothenate	uptake	uptake		[62, 128, 129]
Nicotinamide/nicotinate	uptake	uptake		[43, 128]
Folate	uptake	uptake		[128, 129]
4-aminobenzoic acid	uptake	uptake		[128, 129]
ADP	uptake/secretion	uptake	secretion in early blood stage when ATP can still be salvaged from host	[65, 128, 129]
ATP	uptake/secretion	secretion	uptake in early blood stage when host glycolysis is not repressed yet	[65, 128, 129]
Glycerol	uptake/secretion	uptake/secretion		[128, 129]
Glutathione conjugate	secretion	secretion		[63, 128, 129]
Ornithine	mostly secretion	secretion		[43]
Cholesterol	uptake	uptake		[128]
Formate	no exchange	secretion	Erythrocyte lacks reactions and transport processes to dispose of metabolite	[128, 129]
Fe2+	no exchange/uptake	uptake		[128, 129]
H+	Mostly secretion	secretion		[128, 129]
HC03-	no exchange	secretion	Erythrocyte lacks reactions and transport processes to dispose of metabolite	[128, 129]

ISSN: 1752-0509