Figure 6

Time course simulations in the Full Model. A-D. Response to reoxygenation. Reoxygenation in the hypothetical case of constitutively active FIH that is not affected by competing ARs (A and B) or in the case of an FIH/AR-interaction (C and D), from either severe hypoxia (${\tilde{O}}_2$ = 0.001, A and C, dark grey area) or moderate hypoxia (${\tilde{O}}_2$ = 0.01, B and D, light grey area) to normoxic conditions (${\tilde{O}}_2$ = 0.5) at t = 0. E, F. Response to hypoxia in the case of an FIH/AR-interaction. At t = 0, oxygen levels were changed from normoxic (${\tilde{O}}_2$ = 0.5) to either severely hypoxic (${\tilde{O}}_2$ = 0.001, E, dark grey area) or moderately hypoxic (${\tilde{O}}_2$ = 0.01, F, light grey area). For completion, the behaviour in response to the same changes in oxygen levels but in the hypothetical absence of an FIH/AR-interaction is shown in Additional File 3, Figure S3. Parameters were A _tot = 100, γ = 0.02 and ε = 5 for all of Figures 6 and S3. Time is given in units of the mean life time of HIFα in the absence of oxygen (τ_H).