Figure 4From: A predictive computational model of the kinetic mechanism of stimulus-induced transducer methylation and feedback regulation through CheY in archaeal phototaxis and chemotaxisTransient transducer demethylation rates and CheYp levels for different kinetic mechanisms and models. Orange bars indicate the time intervals of stimulation with attractant orange light. (A) The CheYp-level adapts (bottom) in Model 1, but only E. coli-type methanol release patterns (top) are obtained, irrespective of the chosen parameters. (A inset) A variation of Model 1 that demonstrates the inverted repellent response of mutant cells to normally attractant orange light [55]. (B) The CheYp-level adapts (top, inset) in Model 2, but only E. coli-type methanol release patterns (top) are produced on changes in activity (ΔA): if reaction rates dm A and dm I depend linear on activity A, changes in the rates (Δdm A , Δdm I ) almost compensate each other and no net increase of demethylation occurs (bottom). (C) The CheYp-level adapts (top, inset) in Model 3 and Halobacterium-type methanol release patterns (top) can occur in Model 3 with antagonistic methylation and transducer modification rates that depend quadratic on A (bottom).Back to article page