Figure 4
From: Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin
Heterogeneous responses of stochastically simulated B cells under continuous stimulation with 10 μg/ml LPS for 72 h. Of the five simulated B cells, two cells clearly turn on the bistable switch, becoming IgM-secreting plasma cells; the other three remain unresponsive. Dashed gray lines are trajectories from deterministic simulations, indicating that the bistable circuit is not switched on with the same set of parameter values in a deterministic model.