Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Maier, Klaus; Hofmann, Ute; Reuss, Matthias; Mauch, Klaus

doi:10.1186/1752-0509-4-54

BMC Systems Biology

Table 3 Partial flux control coefficients for succinate-CoA ligase (r33), fumarate hydratase (r34), succinate dehydrogenase (r40), and the malic enzyme (r43)

From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

	r33					r34			r40					r43
	Partial flux control coefficient through				Flux control coefficient	Partial flux control coefficient through		Flux control coefficient	Partial flux control coefficient through				Flux control coefficient	Partial flux control coefficient through				Flux control coefficient
Enzyme	ATP_in	SUC_in	SUCCOA_in	ADP_in		MAL_in	FUM_in		NAD_in	SUC_in	FUM_in	NADH_in		PYR_in	NADP_in	MAL_in	NADPH_in
r1	-0.005	-0.196	0.018	-0.002	-0.185	-0.598	0.414	-0.185	0.000	0.126	-0.247	-0.063	-0.185	-0.060	-0.127	0.085	-0.227	-0.328
r2	-0.003	0.003	-0.001	-0.001	-0.002	0.089	-0.091	-0.002	0.000	-0.002	0.055	-0.055	-0.002	-0.025	0.017	-0.013	0.030	0.009
r3	-0.003	-0.009	0.000	-0.002	-0.014	0.061	-0.075	-0.014	0.000	0.006	0.045	-0.064	-0.014	-0.032	0.011	-0.009	0.019	-0.010
r4	-0.004	-0.012	0.000	-0.002	-0.018	0.077	-0.094	-0.018	0.000	0.008	0.056	-0.081	-0.018	-0.040	0.014	-0.011	0.024	-0.013
r5	-0.001	-0.002	0.000	0.000	-0.002	0.011	-0.013	-0.002	0.000	0.001	0.008	-0.011	-0.002	-0.005	0.002	-0.002	0.003	-0.002
r6	-0.009	-0.028	0.000	-0.005	-0.042	0.178	-0.220	-0.042	-0.001	0.018	0.132	-0.191	-0.042	-0.093	0.031	-0.025	0.056	-0.032
r7	0.000	0.000	0.000	0.000	-0.001	0.003	-0.003	-0.001	0.000	0.000	0.002	-0.003	-0.001	-0.001	0.000	0.000	0.001	0.000
r8	0.000	-0.006	0.001	0.000	-0.006	-0.026	0.020	-0.006	0.000	0.004	-0.012	0.002	-0.006	-0.021	0.002	0.004	0.003	-0.013
r9	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
r10	0.036	-0.544	0.064	0.019	-0.425	-3.145	2.720	-0.425	0.003	0.349	-1.624	0.847	-0.425	0.315	-0.631	0.449	-1.131	-0.998
r11	0.002	-0.025	0.003	0.001	-0.019	-0.143	0.123	-0.019	0.000	0.016	-0.074	0.038	-0.019	0.014	-0.029	0.020	-0.051	-0.045
r12	-0.012	-0.047	0.001	-0.006	-0.065	0.196	-0.261	-0.065	-0.001	0.030	0.156	-0.250	-0.065	-0.125	0.033	-0.028	0.060	-0.060
r13	0.002	0.006	0.000	0.001	0.009	-0.034	0.043	0.009	0.000	-0.004	-0.026	0.038	0.009	0.019	-0.006	0.005	-0.011	0.006
r14	-0.026	-0.090	0.002	-0.013	-0.127	0.422	-0.549	-0.127	-0.002	0.058	0.328	-0.510	-0.127	-0.253	0.073	-0.060	0.131	-0.108
r15	0.011	0.032	0.000	0.006	0.048	-0.209	0.257	0.048	0.001	-0.020	-0.153	0.221	0.048	0.109	-0.037	0.030	-0.066	0.035
r16	-0.017	-0.050	0.000	-0.009	-0.075	0.322	-0.398	-0.075	-0.001	0.032	0.238	-0.344	-0.075	-0.170	0.057	-0.046	0.102	-0.056
r17	0.000	0.000	0.000	0.000	0.000	-0.001	0.001	0.000	0.000	0.000	0.000	0.000	0.000	-0.001	0.000	0.000	0.000	0.000
r18	-0.019	0.532	-0.058	-0.010	0.446	2.173	-1.728	0.446	-0.001	-0.342	1.031	-0.243	0.446	1.168	0.052	-0.310	0.093	1.003
r19	0.061	-0.324	0.048	0.032	-0.182	-2.522	2.340	-0.182	0.004	0.208	-1.397	1.004	-0.182	-1.099	0.004	0.360	0.007	-0.729
r20	0.000	0.000	-0.001	0.000	-0.001	0.004	-0.005	-0.001	0.000	0.000	0.003	-0.004	-0.001	-0.002	0.000	-0.001	-0.001	-0.004
r21	0.000	0.000	0.000	0.000	0.000	-0.001	0.001	0.000	0.000	0.000	-0.001	0.001	0.000	0.000	0.000	0.000	0.000	0.000
r22	0.002	0.751	-0.074	0.001	0.680	2.787	-2.107	0.680	0.000	-0.482	1.258	-0.096	0.680	0.069	0.579	-0.398	1.037	1.287
r23	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	-0.001	0.000	0.000	0.001	0.000
r24	0.001	0.003	0.000	0.000	0.004	-0.018	0.022	0.004	0.000	-0.002	-0.013	0.019	0.004	0.009	-0.003	0.003	-0.006	0.003
r25	0.000	-0.002	0.000	0.000	-0.002	-0.012	0.010	-0.002	0.000	0.001	-0.006	0.003	-0.002	-0.007	0.001	0.002	0.001	-0.004
r26	0.000	0.000	0.000	0.000	0.000	-0.002	0.002	0.000	0.000	0.000	-0.001	0.001	0.000	-0.001	0.000	0.000	0.000	0.000
r27	0.000	0.000	0.000	0.000	0.000	0.007	-0.006	0.000	0.000	0.000	0.004	-0.003	0.000	-0.002	0.001	-0.001	0.002	0.000
r28	0.000	0.005	-0.001	0.000	0.005	0.023	-0.019	0.005	0.000	-0.003	0.011	-0.003	0.005	0.018	-0.001	-0.003	-0.002	0.011
r29	0.004	0.146	-0.008	0.002	0.144	0.584	-0.440	0.144	0.000	-0.094	0.263	-0.024	0.144	0.230	-0.018	-0.083	-0.032	0.098
r30	-0.001	0.010	-0.001	0.000	0.008	0.077	-0.069	0.008	0.000	-0.006	0.041	-0.027	0.008	0.009	0.003	-0.011	0.005	0.005
r31	-0.002	0.018	-0.001	-0.001	0.014	0.141	-0.127	0.014	0.000	-0.011	0.076	-0.050	0.014	0.016	0.005	-0.020	0.009	0.009
r32	-0.001	0.010	-0.001	-0.001	0.008	0.084	-0.075	0.008	0.000	-0.007	0.045	-0.030	0.008	0.009	0.003	-0.012	0.005	0.005
r33	-0.001	-0.924	-0.007	0.000	0.068	-0.755	0.823	0.068	0.000	0.592	-0.492	-0.033	0.068	0.014	0.000	0.108	-0.001	0.121
r34	-0.001	0.071	-0.007	0.000	0.063	-0.703	-0.234	0.063	0.000	-0.046	0.139	-0.030	0.063	0.013	0.000	0.100	-0.001	0.112
r35	0.001	0.042	-0.002	0.001	0.041	0.168	-0.126	0.041	0.000	-0.027	0.075	-0.007	0.041	0.066	-0.005	-0.024	-0.009	0.028
r36	0.013	0.503	-0.026	0.007	0.497	2.012	-1.515	0.497	0.000	-0.323	0.904	-0.084	0.497	0.793	-0.061	-0.287	-0.109	0.337
r37	0.000	-0.013	0.015	0.000	0.002	-0.002	0.004	0.002	0.000	0.008	-0.002	-0.004	0.002	0.001	0.000	0.000	0.000	0.002
r38	-0.001	-0.014	0.002	0.000	-0.013	-0.070	0.057	-0.013	0.000	0.009	-0.034	0.012	-0.013	-0.049	0.003	0.010	0.005	-0.031
r39	0.003	-0.061	0.030	0.002	-0.027	-0.360	0.334	-0.027	0.000	0.039	-0.199	0.133	-0.027	-0.034	-0.007	0.051	-0.013	-0.003
r40	-0.001	0.119	-0.011	-0.001	0.106	-1.177	1.284	0.106	0.000	-0.076	-0.766	-0.051	0.106	0.022	-0.001	0.168	-0.001	0.188
r41	-0.040	-0.493	0.062	-0.021	-0.492	-2.273	1.782	-0.492	0.001	0.316	-1.064	0.255	-0.492	-1.765	0.133	0.324	0.239	-1.069
r42	0.004	-0.032	0.022	0.002	-0.004	-0.235	0.231	-0.004	0.000	0.021	-0.138	0.112	-0.004	0.053	-0.013	0.034	-0.023	0.050
r43	-0.006	0.421	-0.043	-0.003	0.369	1.774	-1.405	0.369	-0.001	-0.270	0.839	-0.199	0.369	-0.030	0.006	-0.253	0.011	0.735
r44	0.001	-0.051	0.011	0.001	-0.038	-0.239	0.201	-0.038	0.000	0.032	-0.120	0.049	-0.038	-0.100	-0.002	0.034	-0.004	-0.073
r45	0.000	0.013	-0.001	0.000	0.011	0.053	-0.042	0.011	0.000	-0.008	0.025	-0.006	0.011	0.028	0.001	-0.007	0.002	0.024
r46	0.009	0.260	-0.033	0.005	0.241	1.285	-1.044	0.241	-0.001	-0.167	0.623	-0.214	0.241	0.888	-0.052	-0.183	-0.094	0.558
r47	-0.001	-0.043	0.004	-0.001	-0.041	-0.132	0.091	-0.041	0.000	0.028	-0.055	-0.014	-0.041	-0.013	-0.028	0.019	-0.050	-0.072
r48	0.001	-0.002	-0.005	0.000	-0.005	0.022	-0.027	-0.005	0.000	0.001	0.016	-0.023	-0.005	-0.013	-0.003	-0.003	-0.005	-0.024
r49	0.001	0.022	-0.003	0.001	0.022	0.107	-0.086	0.022	0.000	-0.014	0.051	-0.015	0.022	0.080	-0.005	-0.015	-0.010	0.050

Partial flux control coefficients are only shown for metabolites with non-zero elasticities. The sum of the partial flux control coefficients over all intermediates equals the flux control coefficient. For the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one.

Back to article page

ISSN: 1752-0509

Contact us

General enquiries: ORSupport@springernature.com