Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

BMC Systems Biology

Table 5 Activator and inhibitor influences

Reaction Identifier	EC-Number	Activators	Inhibitors
Glucokinase	2.7.1.2		F6P [76]
Glucose-6-phosphate isomerase	5.3.1.9		6PG [44]
6-phosphofructokinase	2.7.1.11	AMP [16]	CIT [77]
Fructose-bisphosphate aldolase	4.1.2.13		ADP, ATP, E4P, F6P, G1P, G6P, RIBO5P [78]
Triose-phosphate isomerase	5.3.1.1		ATP [79]
Glyceraldehyde-3-phosphate dehydrogenase	1.2.1.12		ADP, ATP [80]
Phosphoglycerate kinase	2.7.2.3		AMP [81]
Pyruvate kinase	2.7.1.40	G6P, F6P, G1P [82], F16P [83]	ALA [84]
Glucose-6-phosphate dehydrogenase	1.1.1.49		ATP [58]
Phosphoglucomutase	5.4.2.2		f16p [85]
UTP-glucose-1-phosphate uridylyltransferase	2.7.7.9		AMP [16]
Alpha-ketoglutarate dehydrogenase	1.2.4.2	ADP [86]	ATP [86]
Valine, isoleucine, methionine metabolism	-	NAD, AKG [87]	GLU, NADH [87]
Isocitrate dehydrogenase	1.1.1.41	ADP [88]
Pyruvate dehydrogenase	1.2.4.1	AMP [89]

Regulatory influences and corresponding literature references. The modulator effects were included in the dynamic network model. In addition to these regulatory influences, the dynamic model did also account for substrate and product effects.

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