Figure 2

Simulated individual cell dynamics. a), b) Mean transition times calculated using IBM and the master equation approach (ME) to reach (a) differentiated states and (b) stem cell states at 5% (red) and at 20% pO₂ (blue). The transition time to stem cell states at 20% pO₂ was not calculated using the ME because the fraction of cells that have reached stem cell states once converged too slowly (see c). Symbols: IBM results, Lines: Master equation. (c) Fraction of cells that reach stem cell states at 20% pO₂ (ME) as a function of initial α and simulation time.