Figure 4
From: Prioritization of disease microRNAs through a human phenome-microRNAome network
Steps in prioritizing the entire microRNAome for a disease of interest. First, a virtual pull-down of each candidate generates a hypothetical microRNA module, defined as a given microRNA (the center of the module) plus its direct network neighbors in the functionally related microRNA network. Second, in each microRNA module, the microRNAs linked to diseases that have similar phenotypes with the disease being investigated are identified. Finally, all candidates are scored and prioritized.