Table 6 Pair-wise interactions among SNPs when GOSemSim threshold=0.27 (P <0.01).

Chromosome1	Chromosome2	Gene1	Gene2	SNP1	SNP2	OR_int	Χ ²	P -value
1	17	intergenic	KCNH6	rs4658673	rs4968656	0.4873	10.52	0.001183
17	17	intergenic	KCNH6	rs11655589	rs4968656	0.5365	10.43	0.001242
11	17	intergenic	intergenic	rs10501570	rs11655589	0.5096	8.76	0.003083
21	21	ERG	ERG	rs2836389	rs2836392	0.5642	7.55	0.006017
8	17	intergenic	intergenic	rs10503868	rs11655589	0.5543	7.49	0.006223
14	21	RAD51L1	ERG	rs11626809	rs2836392	2.4410	7.40	0.00652
1	17	intergenic	intergenic	rs4658673	rs11655589	0.5534	7.37	0.00665
11	17	intergenic	KCNH6	rs10501570	rs4968656	0.5551	6.66	0.009844

Pair-wise interactions among SNPs when GOSemSim threshold=0.27 with P <0.01 significance. For each group of the gene network where gene pairs have > 0.27 similarity value, all the pairwise SNP-SNP interactions are checked using PLINK between SNPs involved in the groups of genes and all the other SNPs selected by the shrunken method. SNPs network is constructed based on the P <0.01 value of PLINK epistasis test. This table shows the detailed results of PLINK where the first two columns are the chromosomes the SNPs located in, the third and forth columns are the corresponding gene symbol of the SNPs, the fifth and sixth columns are the SNP ID and the last three columns are the odds ratio for interaction, χ² test and P value in the PLINK test.

ISSN: 1752-0509