A systems biology approach to identify effective cocktail drugs

BMC Systems Biology

Table 2 Type 2 Diabetes related genes affected

Gene symbol	Corresponding protein name	Ros&Met	Met	Ros
TCF4	Transcription factor 7-like 2	Yes	No	Yes
MAPK8IP1	C-jun-amino-terminal kinase-interacting protein 1	Yes	No	Yes
NEUROD1	Neurogenic differentiation factor 1	Yes	No	Yes
HNF4A	Hepatocyte nuclear factor 4-alpha	Yes	No	No
IRS1	Insulin receptor substrate 1	Yes	No	Yes
IRS2	Insulin receptor substrate 2	No	Yes	No
AKT2	RAC-beta serine/threonine-protein kinase	No	Yes	No
AXL	Protein AXL2	Yes	No	Yes
ERBB2	Receptor tyrosine-protein kinase erbB-2	Yes	No	Yes
PCSK2	Neuroendocrine convertase 2	Yes	No	Yes
RBP4	Retinol-binding protein 4	Yes	No	Yes
SLC8A1	Sodium/calcium exchanger 1	Yes	No	Yes
IKBKAP	Elongator complex protein 1	Yes	No	No
SMARCA4	Probable global transcription activator SNF2L4	Yes	Yes	No
PMP22	Peripheral myelin protein 22	Yes	Yes	No
CSF1R	Macrophage colony-stimulating factor 1 receptor	Yes	Yes	Yes
RAG1	V(D)J recombination-activating protein 1	Yes	Yes	Yes
PLCE1	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1	Yes	Yes	No
SHC1	SHC-transforming protein 1	No	No	Yes

ISSN: 1752-0509