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Table 1 Reactions that form the metabolic pathways of acidogenesis and solventogenesis and the enzymes which are required to catalyze the solvent-associated reactions, i.e. 3-7 and 9.

From: A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture

Reaction number

Reaction

Associated enzyme(s)

1

glucose → acetyl-CoA

 

2

acetyl-CoA → acetate

 

3

acetate + acetoacetyl-CoA → acetoacetate + acetyl-CoA

CtfA/B

4

acetyl-CoA → acetoacetyl-CoA

ThlA

5

acetyl-CoA → ethanol

AdhE

6

butyrate + acetoacetyl-CoA → acetoacetate + butyryl-CoA

CtfA/B

7

acetoacetate → acetone

Adc

8

butyryl-CoA → butyrate

 

9

butyryl-CoA → butanol

AdhE, BdhA/B

10

acetoacetyl-CoA → butyryl-CoA