Global transcription regulation of RK2 plasmids: a case study in the combined use of dynamical mathematical models and statistical inference for integration of experimental data and hypothesis exploration

Table 3 Estimated protein synthesis rates and their adequate scaling parameters for five different models

Model	k_A[s^-1]		π _X		k_B[s^-1]		π _Y
	m	cv	m	cv	m	cv	m	cv
11	7.9	0.2	-	-	2.3	0.2	-	-
uu	11.5	1.4	0.72	0.5	3.2	1.3	0.72	0.4
u0	14.0	2.4	0.75	0.45	4.0	2.5	-	-
0u	43.0	1.5	-	-	11.6	1.6	0.8	0.4
00	735.0	0.3	-	-	231.0	0.2	-	-

k_A, k_B - protein synthesis rate for KorA and KorB, respectively; π_X,π_Y - scaling parameter for KorA-DNA and KorB-DNA complexes respectively; m - median; cv - coefficient of variation; models: the first and second signs stand for expression from complexes when KorA or KorB are bound to the DNA, respectively, 1- no repression, u - partial repression, 0 - total repression

ISSN: 1752-0509